Document Detail

The production of mutagens in the intestine of mice fed on a diet containing 15% sorbic acid (I).
MedLine Citation:
PMID:  6348301     Owner:  NLM     Status:  MEDLINE    
When mice were fed on a diet containing 15% sorbic acid for a period up to 6 months, ether extracts of the intestinal contents of the mice were not mutagenic with Salmonella typhimurium TA98, but the acidic components obtained by fractionating the ether extracts, showed slightly mutagenic activity with S. typhimurium TA98, and they required the addition of liver 9,000 xg supernatant fraction for mutagenic activation. These results suggested that mutagens were gradually produced in the intestine and moved into the liver where they were metabolically activated. It is possible to presume that liver carcinoma might be attributable to the production of these mutagens.
T Tsuchiya; T Yamaha
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of toxicological sciences     Volume:  8     ISSN:  0388-1350     ISO Abbreviation:  J Toxicol Sci     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-09-23     Completed Date:  1983-09-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7805798     Medline TA:  J Toxicol Sci     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  15-24     Citation Subset:  IM    
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MeSH Terms
Fatty Acids, Unsaturated / metabolism*
Intestines / metabolism*
Mice, Inbred ICR
Mutagens / metabolism*
Rats, Inbred Strains
Salmonella typhimurium / drug effects
Sorbic Acid / metabolism*
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 0/Mutagens; 110-44-1/Sorbic Acid

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