Document Detail


The production of mannan-binding lectin is dependent upon thyroid hormones regardless of the genotype: a cohort study of 95 patients with autoimmune thyroid disorders.
MedLine Citation:
PMID:  20356797     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Complement mannan-binding lectin (MBL) deficiency is associated with increased susceptibility to infections and autoimmune diseases. Previous studies suggested that the production of MBL is stimulated by thyroid hormones. The aim of our study was to investigate this association in patients with autoimmune thyroid diseases (AITD). Serum levels of MBL and parameters of the thyroid function were determined in 62 patients with Hashimoto's thyroiditis, 33 with Graves' disease and 47 blood donors. Follow-up measurements were performed after 6 to 24 months. MBL2 genotypes were determined using multiplex PCR and compared to 359 healthy Czech individuals. Serum levels of MBL tightly correlated with thyroid hormones, leading to strongly increased MBL levels in hyperthyroidism and decreased levels in hypothyroidism. With normalization of the thyroid function during follow-up, MBL levels decreased or increased respectively. The observed correlations were not due to MBL polymorphisms since the frequency of MBL2 polymorphisms in AITD patients was not different from the general population. We conclude that AITD are not associated with MBL polymorphisms. However, the MBL production is strongly dependent on thyroid function, regardless of the genotype.
Authors:
Eliska Potlukova; Jan Jiskra; Tomas Freiberger; Zdenka Limanova; Dana Zivorova; Karin Malickova; Drahomira Springer; Lucie Grodecka; Marie Antosova; Zdenek Telicka; Satu Sinikka Pesickova; Marten Trendelenburg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-30
Journal Detail:
Title:  Clinical immunology (Orlando, Fla.)     Volume:  136     ISSN:  1521-7035     ISO Abbreviation:  Clin. Immunol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-23     Completed Date:  2010-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883537     Medline TA:  Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  123-9     Citation Subset:  IM    
Copyright Information:
(c) 2010 Elsevier Inc. All rights reserved.
Affiliation:
Third Department of Medicine, General University Hospital and First Faculty of Medicine, Charles University in Prague, Czech Republic. eliska.potlukova@seznam.cz
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
C-Reactive Protein / metabolism
Czech Republic
Female
Genotype
Graves Disease / blood*
Hashimoto Disease / blood*
Humans
Male
Mannose-Binding Lectin / blood*,  genetics*
Middle Aged
Polymorphism, Genetic / genetics
Thyroid Hormones / blood*
Thyrotropin / blood
Thyroxine / blood
Triiodothyronine / blood
Young Adult
Chemical
Reg. No./Substance:
0/MBL2 protein, human; 0/Mannose-Binding Lectin; 0/Thyroid Hormones; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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