Document Detail

The production of MLR-blocking factors after lymphocyte immunotherapy for RSA does not predict the outcome of pregnancy.
MedLine Citation:
PMID:  9580175     Owner:  NLM     Status:  MEDLINE    
PROBLEM: The questions of whether production of mixed lymphocyte reaction-blocking factors (MLR-BFs) after immunotherapy with lymphocytes for recurrent spontaneous abortion (RSA) has prognostic value and whether cytotoxic antibodies are also involved were tested. METHOD OF STUDY: A prospective study with 33 patients who had a history of two or more abortions, lacking MLR-BFs, was carried out. The patients received immunizations with lymphocytes and 6 weeks or later were tested for seroconversion of MLR-BFs. Seventeen of these thirty-three patients were evaluated for antipaternal cytotoxic antibodies. The results were correlated with the outcome of the next pregnancy after treatment. RESULTS: Eighty percent of the 33 patients had a live child. Of those patients having success, only 50% produced MLR-BFs. Of those patients having a new loss, five did and two did not produce MLR-BF (P > 0.05). Regarding the 17 patients tested for cytotoxic antibodies, 4 of the 5 patients who tested positive had a new abortion, whereas only 1 of 12 whose tests remained negative did not have gestational success (P < 0.01). CONCLUSION: The presence of MLR-BFs is not a prognostic criterium for the outcome of pregnancy after alloimmunotherapy, and, consequently, it is not a good diagnostic tool for RSA of alloimmune cause.
R B Peña; A P Cadavid; J H Botero; G P García; M I Gallego; J E Ossa
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Publication Detail:
Type:  Clinical Trial; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  39     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-04-28     Completed Date:  1998-04-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  120-4     Citation Subset:  IM    
Reproduction Program, School of Medicine, University of Antioquia, Medellín-Colombia.
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MeSH Terms
Abortion, Habitual / immunology*,  therapy*
Antibodies, Blocking / biosynthesis*
Cytotoxicity, Immunologic
Infant, Newborn
Isoantibodies / biosynthesis
Lymphocyte Culture Test, Mixed
Lymphocytes / immunology
Pregnancy Outcome
Prospective Studies
Reg. No./Substance:
0/Antibodies, Blocking; 0/Isoantibodies

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