| The production of JAK2 wild-type platelets is not downregulated in patients with JAK2 V617F mutant-positive essential thrombocythaemia. | |
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MedLine Citation:
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PMID: 19222478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To clarify the relationship between the levels of JAK2 wild-type (WT) and V617F mutant-positive platelets in patients with essential thrombocythaemia (ET), we quantified mutant levels in purified cells from 10 V617F-positive patients prior to receiving cytoreductive therapy. Mutant levels were significantly higher in platelet than neutrophil RNA (P = 0.002), but the mutation was still only present in a sub-population of platelets (median 54%). When the absolute number of WT platelets was calculated, it was always within or above the normal platelet range, indicating that there is an aberration in the negative feedback to JAK2 WT platelets in ET. |
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Authors:
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Jonathan R Lambert; Rosemary E Gale; David C Linch |
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Publication Detail:
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Type: Journal Article Date: 2009-01-12 |
Journal Detail:
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Title: British journal of haematology Volume: 145 ISSN: 1365-2141 ISO Abbreviation: Br. J. Haematol. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-18 Completed Date: 2009-06-19 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: England |
Other Details:
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Languages: eng Pagination: 128-30 Citation Subset: IM |
Affiliation:
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Department of Haematology, University College London Cancer Institute, London, UK. jonathan.lambert@ucl.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Platelets
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enzymology Humans Janus Kinase 2 / genetics* Mutation* Neutrophils / enzymology Platelet Count RNA / genetics Reverse Transcriptase Polymerase Chain Reaction Thrombocythemia, Essential / blood*, enzymology, genetics |
| Chemical | |
Reg. No./Substance:
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63231-63-0/RNA; EC 2.7.10.1/Janus Kinase 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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