Document Detail

The production of JAK2 wild-type platelets is not downregulated in patients with JAK2 V617F mutant-positive essential thrombocythaemia.
MedLine Citation:
PMID:  19222478     Owner:  NLM     Status:  MEDLINE    
To clarify the relationship between the levels of JAK2 wild-type (WT) and V617F mutant-positive platelets in patients with essential thrombocythaemia (ET), we quantified mutant levels in purified cells from 10 V617F-positive patients prior to receiving cytoreductive therapy. Mutant levels were significantly higher in platelet than neutrophil RNA (P = 0.002), but the mutation was still only present in a sub-population of platelets (median 54%). When the absolute number of WT platelets was calculated, it was always within or above the normal platelet range, indicating that there is an aberration in the negative feedback to JAK2 WT platelets in ET.
Jonathan R Lambert; Rosemary E Gale; David C Linch
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Publication Detail:
Type:  Journal Article     Date:  2009-01-12
Journal Detail:
Title:  British journal of haematology     Volume:  145     ISSN:  1365-2141     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-18     Completed Date:  2009-06-19     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  128-30     Citation Subset:  IM    
Department of Haematology, University College London Cancer Institute, London, UK.
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MeSH Terms
Blood Platelets / enzymology
Janus Kinase 2 / genetics*
Neutrophils / enzymology
Platelet Count
RNA / genetics
Reverse Transcriptase Polymerase Chain Reaction
Thrombocythemia, Essential / blood*,  enzymology,  genetics
Reg. No./Substance:
63231-63-0/RNA; EC Kinase 2

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