Document Detail


The process of mRNA-tRNA translocation.
MedLine Citation:
PMID:  18003906     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the elongation cycle of translation, translocation is the process that advances the mRNA-tRNA moiety on the ribosome, to allow the next codon to move into the decoding center. New results obtained by cryoelectron microscopy, interpreted in the light of x-ray structures and kinetic data, allow us to develop a model of the molecular events during translocation.
Authors:
Joachim Frank; Haixiao Gao; Jayati Sengupta; Ning Gao; Derek J Taylor
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-11-14
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  104     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-14     Completed Date:  2008-01-11     Revised Date:  2010-09-16    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  19671-8     Citation Subset:  IM    
Affiliation:
Howard Hughes Medical Institute and Health Research Incorporated, Wadsworth Center, Empire State Plaza, Albany, NY 12201-0509, USA. joachim@wadsworth.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport
Catalysis
Guanosine Triphosphate / metabolism
Humans
Hydrolysis
Models, Genetic
Peptide Elongation Factor G / chemistry,  metabolism
RNA, Messenger / chemistry,  genetics,  metabolism,  ultrastructure
RNA, Transfer / chemistry,  genetics,  metabolism*,  ultrastructure
Ribosomes / chemistry,  metabolism
Grant Support
ID/Acronym/Agency:
P41 RR01219/RR/NCRR NIH HHS; R01 GM55440/GM/NIGMS NIH HHS; R37 GM29169/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Peptide Elongation Factor G; 0/RNA, Messenger; 86-01-1/Guanosine Triphosphate; 9014-25-9/RNA, Transfer
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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