Document Detail

The problem of malaria and malaria control in pregnancy in sub-Saharan Africa.
MedLine Citation:
PMID:  8702033     Owner:  NLM     Status:  MEDLINE    
Plasmodium falciparum infection in pregnant women frequently leads to placental infection and low birth weight (< 2,500 grams) of the infant, particularly in the areas of high malaria transmission found in sub-Saharan Africa. Low birth weight is widely known to be an important risk factor for early infant mortality. To reduce the risk that maternal infection poses to child survival, many antenatal clinic programs recommend and provide antimalarial chemoprophylaxis, often with chloroquine (CQ) as a recommended element for antenatal care. Prior to the 1980s, despite widespread advocacy for this intervention, little was known about the effect of this intervention strategy. As an introduction to the Mangochi Malaria Research Project, which examined the efficacy of several antimalarial regimens using CQ or mefloquine in pregnant women in Malawi, we describe the background of knowledge regarding malaria infection in pregnant African women and the important elements of an intervention and prevention strategy.
R W Steketee; J J Wirima; L Slutsker; D L Heymann; J G Breman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  55     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  1996  
Date Detail:
Created Date:  1996-09-04     Completed Date:  1996-09-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2-7     Citation Subset:  AIM; IM    
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
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MeSH Terms
Africa South of the Sahara
Antimalarials / therapeutic use*
Fetal Death
Immunity, Maternally-Acquired
Infant, Low Birth Weight
Infant, Newborn
Infectious Disease Transmission, Vertical*
Malaria, Falciparum / complications,  prevention & control*,  transmission
Pregnancy Complications, Parasitic / prevention & control*
Pregnancy Outcome*
Reg. No./Substance:

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