| The problem of avascular necrosis of bone in patients treated for Hodgkin's disease. | |
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MedLine Citation:
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PMID: 6825406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Seven patients treated for Hodgkin's disease by chemotherapy and radiotherapy developed avascular necrosis of the heads of long bones (femur in six cases, humerus in one case). The use of steroids has been correlated with the appearance of this uncommon complication but steroids may not be the only aetiological factor. The roles of radiotherapy, chemotherapeutic agents and trauma have not been clarified in previously published accounts. The importance of trauma as a cofactor is emphasised and it is suggested that patients at risk try to avoid trauma and excessive mechanical stress. The role of radiation is less clear, though shielding the heads of long bones is recommended when clinically appropriate. Early orthopaedic referral with hip-joint replacement or bone grafting reduces the short-term morbidity of this condition, though the long-term prognosis after surgery is uncertain. Although this complication of treatment is uncommon it may inflict disability and occupational disturbance on otherwise healthy patients who have the prospect of long-term survival. |
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Authors:
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J J Mould; N M Adam |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical radiology Volume: 34 ISSN: 0009-9260 ISO Abbreviation: Clin Radiol Publication Date: 1983 Mar |
Date Detail:
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Created Date: 1983-04-15 Completed Date: 1983-04-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1306016 Medline TA: Clin Radiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 231-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Antineoplastic Agents / adverse effects Drug Therapy, Combination Femur Head Necrosis / etiology, radiography Hodgkin Disease / therapy* Humans Male Occupations Osteonecrosis / etiology*, radiography Prednisolone / adverse effects Radiotherapy / adverse effects Sex Factors |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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