Document Detail

A probiotics-containing biscuit modulates the intestinal microbiota in the elderly.
MedLine Citation:
PMID:  23364497     Owner:  NLM     Status:  In-Data-Review    
Objectives: Evaluation of the impact of a biscuit containing the probiotics Bifidobacterium longum Bar33 and Lactobacillus helveticus Bar13 on the intestinal microbiota in the elderly. Design: Randomized double-blind placebo-controlled trial. Participants: Thirty-two elderly volunteers living in Italy. The group was composed of 19 women and 13 men aged between 71 and 88 years (mean 76). Intervention: Subjects were randomized in two groups consuming one dose of the probiotics-containing biscuit or placebo once a day for 30 days. Measurements: For each subject the intestinal microbiota was characterized using the phylogenetic microarray platform HTF-Microbi.Array before and after intervention. Results: Our data demonstrated that one-month consumption of a probiotics-containing biscuit was effective in redressing some of the age-related dysbioses of the intestinal microbiota. In particular, the probiotic treatment reverted the age-related increase of the opportunistic pathogens Clostridium cluster XI, Clostridium difficile, Clostridium perfringens, Enterococcus faecium and the enteropathogenic genus Campylobacter. Conclusion: The present study opens the way to the development of elderly-tailored probiotic-based functional foods to counteract the age-related dysbioses of the intestinal microbiota.
S Rampelli; M Candela; M Severgnini; E Biagi; S Turroni; M Roselli; P Carnevali; L Donini; P Brigidi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of nutrition, health & aging     Volume:  17     ISSN:  1760-4788     ISO Abbreviation:  J Nutr Health Aging     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100893366     Medline TA:  J Nutr Health Aging     Country:  France    
Other Details:
Languages:  eng     Pagination:  166-72     Citation Subset:  IM    
S. Rampelli, Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy.
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