Document Detail


A probable explanation for mild extra-articular manifestations in Indian patients of rheumatoid arthritis: a preliminary study.
MedLine Citation:
PMID:  9805851     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One hundred four Rheumatoid factor (RF) positive Rheumatoid Arthritis (RA) patients fulfilling ARA criteria were screened for extraarticular manifestations. Rheumatoid nodules were present in 2.8% cases. Other extraarticular manifestations such as pulmonary, cardiac, occular, renal or GI involvement were absent in these cases. However, circulating immune complexes (CICs) were highly significantly raised in all the RA patients (P < 0.001). From amongst these cases a limited number (8 cases) have been subjected to qualitative and quantitative analysis of CICs to look for whether there could be any relationship between these and mild extraarticular manifestations that were being noticed in our groups of patients. Finding showed IgG-IgG CICs in five, IgG-IgM in two and IgG-IgA in one case. Quantitative analysis revealed mean IgG 4.97 +/- 1.7 IU/ml, IgM 14.58 +/- 5.53 IU/ml and IgA 5.08 +/- 1.53 IU/ml on LD Solugen plates. Serum concentration of C3 was not reduced (94.1 +/- 8.9 mg/dl). Low IgM contents of CICs and no reduction in complement level is the likely explanation for less severe inflammatory manifestations seen in our study. The conclusion and findings have been discussed in the light of observation reported by the Western workers.
Authors:
V Agrawal; Usha; S C Goel; R M Gupta
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of pathology & microbiology     Volume:  41     ISSN:  0377-4929     ISO Abbreviation:  Indian J Pathol Microbiol     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-12-02     Completed Date:  1998-12-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7605904     Medline TA:  Indian J Pathol Microbiol     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  297-301     Citation Subset:  IM    
Affiliation:
Advance UGC Immunodiagnostic Training and Research Centre, IMS, BHU, Varanasi.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigen-Antibody Complex / blood*
Arthritis, Rheumatoid / blood,  immunology*,  physiopathology*
Female
Humans
Immunoglobulin A / blood
Immunoglobulin G / blood
Immunoglobulin M / blood
India
Male
Reference Values
Rheumatoid Factor / blood
Chemical
Reg. No./Substance:
0/Antigen-Antibody Complex; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; 9009-79-4/Rheumatoid Factor

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