| A probable clinically significant interaction between warfarin and cloxacillin: three case reports. | |
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MedLine Citation:
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PMID: 22945792 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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CASES: Three patients were admitted to the Imam Hospital, Tehran, Iran with a diagnosis of bacterial endocarditis. The patients had indications for valve replacement surgery and anticoagulant therapy. The administration of cloxacillin reduced the effect of warfarin, and subsequent increases in warfarin doses were unable to overcome this effect. CONCLUSION: A decrease in warfarin anticoagulation effects was detected in our three patients following cloxacillin therapy for infective endocarditis. Penicillinase-resistant penicillins remain essential antibiotics in the treatment of severe infections caused by Staphylococcus aureus due to their bactericidal activity, safety, and cost. Thus, in situations where anticoagulants are indicated in patients with infective endocarditis, it would be better to replace warfarin with low-molecular-weight or unfractionated heparin. |
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Authors:
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Hossein Khalili; Naemeh Nikvarz; Farhad Najmeddin; Simin Dashti-Khavidaki |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-4 |
Journal Detail:
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Title: European journal of clinical pharmacology Volume: - ISSN: 1432-1041 ISO Abbreviation: Eur. J. Clin. Pharmacol. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1256165 Medline TA: Eur J Clin Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155/6451, Tehran, 1417614411, Iran, khalilih@tums.ac.ir. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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