Document Detail

On the probability that kidneys are different in autosomal dominant polycystic disease.
MedLine Citation:
PMID:  1453604     Owner:  NLM     Status:  MEDLINE    
We hypothesized that highly variable cyst fluid sodium concentrations are a characteristic of every kidney in autosomal dominant polycystic kidney disease (ADPKD). We added our data on sodium concentrations in 124 fluids from ten ADPKD kidneys to data published by others of concentrations in 32 fluids from five kidneys. The values ranged from 3 to 207 mEq/liter; none fell between 59 and 74 mEq/liter. Fluids were designated as low (< 60 mEq/liter; 50 fluids) or high (> 60 mEq/liter; 106 fluids) sodium fluids. Transmission electron microscopy identified differences in the depths of apical tight junctions between cells from cyst walls of 12 of the low and 10 of the high sodium fluids from two kidneys (mean +/- SE depths of 2039 +/- 74 A vs. 386 +/- 18 A respectively; P < 0.0001). When fluids were grouped by kidney of origin, six of the 15 kidneys had only high sodium fluids. The probability that chance had led to the sampling of only high sodium fluids in these organs, given that 32% of all fluids were low sodium fluids, was calculated at < 0.00015. The possibility must be considered that all kidneys are not alike in ADPKD.
K D Gardner; J S Burnside; B J Skipper; S K Swan; W M Bennett; B A Connors; A P Evan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Kidney international     Volume:  42     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-01-07     Completed Date:  1993-01-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1199-206     Citation Subset:  IM    
Department of Medicine, University of New Mexico School of Medicine, Albuquerque.
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MeSH Terms
Body Fluids / metabolism
Creatinine / metabolism
Intercellular Junctions / metabolism,  ultrastructure
Kidney / metabolism*,  ultrastructure
Microscopy, Electron
Microscopy, Electron, Scanning
Middle Aged
Osmolar Concentration
Polycystic Kidney, Autosomal Dominant / metabolism*,  pathology
Sodium / metabolism*
Tissue Distribution
Reg. No./Substance:
60-27-5/Creatinine; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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