| The probability of neonatal respiratory distress syndrome as a function of gestational age and lecithin/sphingomyelin ratio. | |
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MedLine Citation:
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PMID: 18773379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We sought to define the risk of neonatal respiratory distress syndrome (RDS) as a function of both lecithin/sphingomyelin (L/S) ratio and gestational age. Amniotic fluid L/S ratio data were collected from consecutive women undergoing amniocentesis for fetal lung maturity at Yale-New Haven Hospital from January 1998 to December 2004. Women were included in the study if they delivered a live-born, singleton, nonanomalous infant within 72 hours of amniocentesis. The probability of RDS was modeled using multivariate logistic regression with L/S ratio and gestational age as predictors. A total of 210 mother-neonate pairs (8 RDS, 202 non-RDS) met criteria for analysis. Both gestational age and L/S ratio were independent predictors of RDS. A probability of RDS of 3% or less was noted at an L/S ratio cutoff of > or = 3.4 at 34 weeks, > or = 2.6 at 36 weeks, > or = 1.6 at 38 weeks, and > or = 1.2 at term. Under 34 weeks of gestation, the prevalence of RDS was so high that a probability of 3% or less was not observed by this model. These data describe a means of stratifying the probability of neonatal RDS using both gestational age and the L/S ratio and may aid in clinical decision making concerning the timing of delivery. |
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Authors:
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Caryn St Clair; Errol R Norwitz; Karlijn Woensdregt; Michael Cackovic; Julia A Shaw; Herbert Malkus; Richard A Ehrenkranz; Jessica L Illuzzi |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-09-04 |
Journal Detail:
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Title: American journal of perinatology Volume: 25 ISSN: 1098-8785 ISO Abbreviation: Am J Perinatol Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-10-21 Completed Date: 2008-12-23 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 8405212 Medline TA: Am J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 473-80 Citation Subset: IM |
Affiliation:
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Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520-8063, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amniotic Fluid
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chemistry* Gestational Age* Humans Infant, Newborn Lecithins / analysis* Logistic Models Respiratory Distress Syndrome, Newborn / epidemiology* Risk Assessment Sphingomyelins / analysis* |
| Grant Support | |
ID/Acronym/Agency:
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K 12 HD047918/HD/NICHD NIH HHS; K12 HD047018-07/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lecithins; 0/Sphingomyelins |
| Comments/Corrections | |
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