Document Detail

The probability of neonatal respiratory distress syndrome as a function of gestational age and lecithin/sphingomyelin ratio.
MedLine Citation:
PMID:  18773379     Owner:  NLM     Status:  MEDLINE    
We sought to define the risk of neonatal respiratory distress syndrome (RDS) as a function of both lecithin/sphingomyelin (L/S) ratio and gestational age. Amniotic fluid L/S ratio data were collected from consecutive women undergoing amniocentesis for fetal lung maturity at Yale-New Haven Hospital from January 1998 to December 2004. Women were included in the study if they delivered a live-born, singleton, nonanomalous infant within 72 hours of amniocentesis. The probability of RDS was modeled using multivariate logistic regression with L/S ratio and gestational age as predictors. A total of 210 mother-neonate pairs (8 RDS, 202 non-RDS) met criteria for analysis. Both gestational age and L/S ratio were independent predictors of RDS. A probability of RDS of 3% or less was noted at an L/S ratio cutoff of > or = 3.4 at 34 weeks, > or = 2.6 at 36 weeks, > or = 1.6 at 38 weeks, and > or = 1.2 at term. Under 34 weeks of gestation, the prevalence of RDS was so high that a probability of 3% or less was not observed by this model. These data describe a means of stratifying the probability of neonatal RDS using both gestational age and the L/S ratio and may aid in clinical decision making concerning the timing of delivery.
Caryn St Clair; Errol R Norwitz; Karlijn Woensdregt; Michael Cackovic; Julia A Shaw; Herbert Malkus; Richard A Ehrenkranz; Jessica L Illuzzi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-09-04
Journal Detail:
Title:  American journal of perinatology     Volume:  25     ISSN:  1098-8785     ISO Abbreviation:  Am J Perinatol     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-10-21     Completed Date:  2008-12-23     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  473-80     Citation Subset:  IM    
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MeSH Terms
Amniotic Fluid / chemistry*
Gestational Age*
Infant, Newborn
Lecithins / analysis*
Logistic Models
Respiratory Distress Syndrome, Newborn / epidemiology*
Risk Assessment
Sphingomyelins / analysis*
Grant Support
Reg. No./Substance:
0/Lecithins; 0/Sphingomyelins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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