Document Detail

The probabilistic nature of synaptic transmission at a mammalian excitatory central synapse.
MedLine Citation:
PMID:  3033165     Owner:  NLM     Status:  MEDLINE    
The synaptic connection between single group I afferents and dorsal spinocerebellar tract (DSCT) neurons in the cat spinal cord has been studied in an attempt to gain insight into the mechanisms of excitatory synaptic transmission in the mammalian CNS. Fluctuations in the amplitude of single group I fiber EPSPs in DSCT neurons were examined using a numerical deconvolution procedure to reduce the effects of contaminating noise. In general, it was found that single fiber EPSPs fluctuate in peak amplitude between discrete levels separated by equal or quantal increments. Many previous studies have proposed simple binomial statistics as a general model of quantal synaptic transmission. In the present study we show that simple binomial statistics do not describe the fluctuations in amplitude of single group I fiber EPSPs in DSCT neurons. It is suggested that nonuniformities in the probability of transmitter release from release site to release site explain the failure of the binomial model to describe the EPSP fluctuation pattern at this synapse. Nonuniform quantal transmission is proposed as a more adequate description of excitatory synaptic transmission in the mammalian CNS.
B Walmsley; F R Edwards; D J Tracey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  7     ISSN:  0270-6474     ISO Abbreviation:  J. Neurosci.     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-05-29     Completed Date:  1987-05-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1037-46     Citation Subset:  IM    
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MeSH Terms
Cerebellum / physiology*
Membrane Potentials
Neural Pathways / physiology
Spinal Cord / physiology*
Synapses / physiology*
Synaptic Transmission*

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