| The probabilistic nature of synaptic transmission at a mammalian excitatory central synapse. | |
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MedLine Citation:
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PMID: 3033165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The synaptic connection between single group I afferents and dorsal spinocerebellar tract (DSCT) neurons in the cat spinal cord has been studied in an attempt to gain insight into the mechanisms of excitatory synaptic transmission in the mammalian CNS. Fluctuations in the amplitude of single group I fiber EPSPs in DSCT neurons were examined using a numerical deconvolution procedure to reduce the effects of contaminating noise. In general, it was found that single fiber EPSPs fluctuate in peak amplitude between discrete levels separated by equal or quantal increments. Many previous studies have proposed simple binomial statistics as a general model of quantal synaptic transmission. In the present study we show that simple binomial statistics do not describe the fluctuations in amplitude of single group I fiber EPSPs in DSCT neurons. It is suggested that nonuniformities in the probability of transmitter release from release site to release site explain the failure of the binomial model to describe the EPSP fluctuation pattern at this synapse. Nonuniform quantal transmission is proposed as a more adequate description of excitatory synaptic transmission in the mammalian CNS. |
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Authors:
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B Walmsley; F R Edwards; D J Tracey |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 7 ISSN: 0270-6474 ISO Abbreviation: J. Neurosci. Publication Date: 1987 Apr |
Date Detail:
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Created Date: 1987-05-29 Completed Date: 1987-05-29 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1037-46 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cats Cerebellum / physiology* Membrane Potentials Neural Pathways / physiology Probability Spinal Cord / physiology* Synapses / physiology* Synaptic Transmission* |
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