Document Detail

Is prior cholecystectomy associated with decreased survival in patients with resectable pancreatic adenocarcinoma following pancreaticoduodenectomy?
MedLine Citation:
PMID:  20864079     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Patients with pancreatic cancer who present with biliary symptoms may undergo cholecystectomy and thus delay cancer diagnosis. We hypothesized that prior cholecystectomy leads to decreased overall survival in patients with pancreatic adenocarcinoma.
METHODS: Retrospective study of hepatobiliary database.
RESULTS: Three hundred sixty-five patients with a diagnosis of resectable periampullary pancreatic adenocarcinoma were identified. Eighty-seven patients underwent prior cholecystectomy. Median age (P = .48), body mass index (BMI) (P = .8), diabetes status (P = .06), American Society of Anesthesiologists (ASA) class (P = .22), stent placement (P = .13), operative time (P = .76), estimated blood loss (EBL) (P = .24), intraoperative transfusion (P = .91), portal vein resection (P = .25), LOS (P = .09) adjuvant therapy (P = .2), tumor size (P = .89), differentiation (P = .67), angiolymphatic invasion (P = .69), perineural invasion (P = 54), nodal metastasis (P = .43), complication rate (P = .75), and 30-day mortality (P = .58) were not statistically different between patients with previous cholecystectomy and those without. Median survival was 14 months for patients with a history of cholecystectomy and 16 months for those without (P = .25). Previous cholecystectomy was not a predictor of survival on Cox regression analysis.
CONCLUSION: There was no difference in overall survival in patients with pancreatic cancer with prior cholecystectomy versus those without.
Suzanne C Schiffman; Carrie K Chu; Jaemin Park; Maria Russell; Steven Keilin; David A Kooby; Charles R Scoggins; Kelly M McMasters; Robert C G Martin
Related Documents :
8862089 - Immunocytochemical detection of isolated epithelial tumor cells in bone marrow of patie...
18382099 - Serous cystadenoma of the pancreas: clinical and pathological features in 33 patients.
19502179 - Bortezomib in treatment of extramedullary plasmacytoma of the pancreas.
6372069 - Treatment of unresectable pancreatic carcinoma with 5-fluorouracil, vincristine, and ccnu.
18365539 - Comparison of clinicopathological characteristics of curatively resected pancreatic hea...
20542529 - Anaplastic pancreatic cancer: presentation, surgical management, and outcome.
23957099 - Treatment concepts of oral cancer.
7522349 - Practical approaches to the treatment of patients with extensive stage small cell lung ...
12653949 - Concordance of figo grade of endometrial adenocarcinomas in biopsy and hysterectomy spe...
Publication Detail:
Type:  Journal Article     Date:  2010-09-22
Journal Detail:
Title:  American journal of surgery     Volume:  201     ISSN:  1879-1883     ISO Abbreviation:  Am. J. Surg.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370473     Medline TA:  Am J Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  519-24     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Division of Surgical Oncology, Department of Surgery, University of Louisville, and the James Graham Brown Cancer Center, Louisville, KY, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Flat epithelial atypia of the breast: characteristics and behaviors.
Next Document:  Chronic syphilitic aortic aneurysm complicated with chronic aortic dissection.