| Is prior cholecystectomy associated with decreased survival in patients with resectable pancreatic adenocarcinoma following pancreaticoduodenectomy? | |
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MedLine Citation:
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PMID: 20864079 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Patients with pancreatic cancer who present with biliary symptoms may undergo cholecystectomy and thus delay cancer diagnosis. We hypothesized that prior cholecystectomy leads to decreased overall survival in patients with pancreatic adenocarcinoma. METHODS: Retrospective study of hepatobiliary database. RESULTS: Three hundred sixty-five patients with a diagnosis of resectable periampullary pancreatic adenocarcinoma were identified. Eighty-seven patients underwent prior cholecystectomy. Median age (P = .48), body mass index (BMI) (P = .8), diabetes status (P = .06), American Society of Anesthesiologists (ASA) class (P = .22), stent placement (P = .13), operative time (P = .76), estimated blood loss (EBL) (P = .24), intraoperative transfusion (P = .91), portal vein resection (P = .25), LOS (P = .09) adjuvant therapy (P = .2), tumor size (P = .89), differentiation (P = .67), angiolymphatic invasion (P = .69), perineural invasion (P = 54), nodal metastasis (P = .43), complication rate (P = .75), and 30-day mortality (P = .58) were not statistically different between patients with previous cholecystectomy and those without. Median survival was 14 months for patients with a history of cholecystectomy and 16 months for those without (P = .25). Previous cholecystectomy was not a predictor of survival on Cox regression analysis. CONCLUSION: There was no difference in overall survival in patients with pancreatic cancer with prior cholecystectomy versus those without. |
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Authors:
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Suzanne C Schiffman; Carrie K Chu; Jaemin Park; Maria Russell; Steven Keilin; David A Kooby; Charles R Scoggins; Kelly M McMasters; Robert C G Martin |
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Publication Detail:
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Type: Journal Article Date: 2010-09-22 |
Journal Detail:
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Title: American journal of surgery Volume: 201 ISSN: 1879-1883 ISO Abbreviation: Am. J. Surg. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370473 Medline TA: Am J Surg Country: United States |
Other Details:
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Languages: eng Pagination: 519-24 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Surgical Oncology, Department of Surgery, University of Louisville, and the James Graham Brown Cancer Center, Louisville, KY, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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