Document Detail


A primer on the molecular virology of hepatitis C.
MedLine Citation:
PMID:  15566499     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exciting advances have recently been made in the understanding of the molecular virology of hepatitis C. Powerful model systems have been developed that allow to systematically dissect important steps of the hepatitis C virus (HCV) life cycle. These include new systems for functional analyses of the HCV glycoproteins, providing insights into possible HCV receptors and cell entry mechanisms, and the replicon system, which has revolutionized investigation of HCV RNA replication and has facilitated drug discovery efforts. The largest gaps remain in the understanding of the virion structure and the processes that lead to the assembly, packaging and release of virions. However, given the pace of current HCV research, progress in these directions may be expected in the near future. Here, we provide a primer on the molecular virology of hepatitis C, with particular reference to novel antiviral targets and therapeutic strategies.
Authors:
Darius Moradpour; Hubert E Blum
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Liver international : official journal of the International Association for the Study of the Liver     Volume:  24     ISSN:  1478-3223     ISO Abbreviation:  Liver Int.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-29     Completed Date:  2005-03-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101160857     Medline TA:  Liver Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  519-25     Citation Subset:  IM    
Affiliation:
Department of Medicine II, University of Freiburg, Freiburg, Germany. darius.moradpour@uni-freiburg.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Antiviral Agents / therapeutic use
DNA, Viral / analysis*
Forecasting
Hepacivirus / genetics*,  physiology
Hepatitis C / drug therapy,  epidemiology,  genetics*
Hepatitis C, Chronic / drug therapy,  epidemiology,  genetics
Humans
Liver Cirrhosis / prevention & control
Reverse Transcriptase Polymerase Chain Reaction / methods
Risk Factors
Viral Structural Proteins / analysis,  genetics*
Virus Replication / physiology
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/DNA, Viral; 0/Viral Structural Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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