| The primary cilium coordinates signaling pathways in cell cycle control and migration during development and tissue repair. | |
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MedLine Citation:
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PMID: 19147009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cell cycle control and migration are critical processes during development and maintenance of tissue functions. Recently, primary cilia were shown to take part in coordination of the signaling pathways that control these cellular processes in human health and disease. In this review, we present an overview of the function of primary cilia and the centrosome in the signaling pathways that regulate cell cycle control and migration with focus on ciliary signaling via platelet-derived growth factor receptor alpha (PDGFRalpha). We also consider how the primary cilium and the centrosome interact with the extracellular matrix, coordinate Wnt signaling, and modulate cytoskeletal changes that impinge on both cell cycle control and cell migration. |
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Authors:
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Søren T Christensen; Stine F Pedersen; Peter Satir; Iben R Veland; Linda Schneider |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current topics in developmental biology Volume: 85 ISSN: 0070-2153 ISO Abbreviation: Curr. Top. Dev. Biol. Publication Date: 2008 |
Date Detail:
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Created Date: 2009-01-16 Completed Date: 2009-03-19 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0163114 Medline TA: Curr Top Dev Biol Country: United States |
Other Details:
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Languages: eng Pagination: 261-301 Citation Subset: IM |
Affiliation:
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Department of Biology, Section of Cell and Developmental Biology, The August Krogh Building, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen OE, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / physiology* Cell Movement* Cilia / physiology* Receptor, Platelet-Derived Growth Factor alpha / metabolism Regeneration* Signal Transduction / physiology* Tissue Engineering |
| Chemical | |
Reg. No./Substance:
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EC 2.7.10.1/Receptor, Platelet-Derived Growth Factor alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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