| A primary care evaluation of three near patient coagulometers. | |
| | |
MedLine Citation:
|
PMID: 10690176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIM: To compare the reliability and relative costs of three international normalised ratio (INR) near patient tests. MATERIALS: Protime (ITC Technidyne), Coaguchek (Boehringer Mannheim), and TAS (Diagnostic Testing). METHODS: All patients attending one inner city general practice anticoagulation clinic were asked to participate, with two samples provided by patients not taking warfarin. A 5 ml sample of venous whole blood was taken from each patient and a drop immediately added to the prepared Coaguchek test strip followed by the Protime cuvette. The remainder was added to a citrated bottle. A drop of citrated blood was then placed on the TAS test card and the remainder sent to the reference laboratory for analysis. Parallel INR estimation was performed on the different near patient tests at each weekly anticoagulation clinic from July to December 1997. RESULTS: 19 patients receiving long term warfarin treatment provided 62 INR results. INR results ranged from 0.8-8.2 overall and 1.0-5.7 based on the laboratory method. Taking the laboratory method as the gold standard, 12/62 results were < 2.0 and 2/62 were > 4.5. There were no statistical or clinically significant differences between results from the three systems, although all near patient tests showed slightly higher mean readings than the laboratory, and 19-24% of tests would have resulted in different management decisions based on the machine used in comparison with the laboratory INR value. The cost of the near patient test systems varied substantially. CONCLUSIONS: All three near patient test systems are safe and efficient for producing acceptable and reproducible INR results within the therapeutic range in a primary care setting. All the systems were, however, subject to operator dependent variables at the time of blood letting. Adequate training in capillary blood sampling, specific use of the machines, and quality assurance procedures is therefore essential. |
| | |
Authors:
|
E T Murray; D A Fitzmaurice; T F Allan; F D Hobbs |
Related Documents
:
|
23018776 - Increased allergic sensitization to mugwort in chronic urticaria. 819396 - Three simple tests as an adjunct to the niacin test for the small mycobacteriology labo... 22675386 - Exploration of new electroacupuncture needle material. 23628466 - Verbal fluency deficits in clinically isolated syndrome suggestive of multiple sclerosis. 3630936 - Effect of eating on thallium-201 myocardial redistribution after myocardial ischemia. 17941916 - A general population from thailand: incidence of common allergens with emphasis on para... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of clinical pathology Volume: 52 ISSN: 0021-9746 ISO Abbreviation: J. Clin. Pathol. Publication Date: 1999 Nov |
Date Detail:
|
Created Date: 2000-03-02 Completed Date: 2000-03-02 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 0376601 Medline TA: J Clin Pathol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 842-5 Citation Subset: AIM; IM |
Affiliation:
|
Department of General Practice, Medical School, University of Birmingham, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anticoagulants
/
therapeutic use Blood Coagulation Disorders / drug therapy*, physiopathology Costs and Cost Analysis Evaluation Studies as Topic Humans International Normalized Ratio / economics, instrumentation*, standards Point-of-Care Systems / economics*, standards Quality Assurance, Health Care Sensitivity and Specificity Warfarin / therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Anticoagulants; 81-81-2/Warfarin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Immunohistochemical localisation of androgen receptor in apocrine metaplasia and apocrine adenosis o...
Next Document: Cutaneous Scedosporium apiospermum infection in an immunocompromised patient.