Document Detail


The preventive effect of low-dose aspirin in the development of stress ulceration in rats.
MedLine Citation:
PMID:  6614664     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The preventative effect of low-dose aspirin in the development of stress ulcer induced by cold restraint were examined in Sprague-Dawley rats. The bleeding and ulceration scores in the control group were 2.14 and 13.50, respectively. The bleeding score in the 1 mg/kg aspirin group was 1.32 and the ulceration score was 6.89. The scores in 50 mg/kg aspirin group were 2.86 and 38.74, respectively. A significant decrease of ulceration in low-dose aspirin and significant increase in high-dose aspirin were demonstrated. A significant decrease in gastric acid secretion in the low-dose aspirin group was recognized. However, the inhibition of platelet aggregation induced by low-dose aspirin was thought to play a major role in the prevention of stress ulcer.
Authors:
R Kumashiro; O Montgomery; A Langman; A M Kholoussy; T Matsumoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American surgeon     Volume:  49     ISSN:  0003-1348     ISO Abbreviation:  Am Surg     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1983-10-08     Completed Date:  1983-10-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370522     Medline TA:  Am Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  423-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Aspirin / administration & dosage*
Gastric Acid / secretion
Gastric Mucosa / physiopathology
Male
Peptic Ulcer Hemorrhage / physiopathology
Platelet Aggregation / drug effects
Platelet Count
Rats
Rats, Inbred Strains
Stomach Ulcer / prevention & control*
Stress, Physiological
Chemical
Reg. No./Substance:
50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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