Document Detail

The preventive effect of low-dose aspirin in the development of stress ulceration in rats.
MedLine Citation:
PMID:  6614664     Owner:  NLM     Status:  MEDLINE    
The preventative effect of low-dose aspirin in the development of stress ulcer induced by cold restraint were examined in Sprague-Dawley rats. The bleeding and ulceration scores in the control group were 2.14 and 13.50, respectively. The bleeding score in the 1 mg/kg aspirin group was 1.32 and the ulceration score was 6.89. The scores in 50 mg/kg aspirin group were 2.86 and 38.74, respectively. A significant decrease of ulceration in low-dose aspirin and significant increase in high-dose aspirin were demonstrated. A significant decrease in gastric acid secretion in the low-dose aspirin group was recognized. However, the inhibition of platelet aggregation induced by low-dose aspirin was thought to play a major role in the prevention of stress ulcer.
R Kumashiro; O Montgomery; A Langman; A M Kholoussy; T Matsumoto
Related Documents :
8139094 - Effects of ng-monomethyl-l-arginine, indomethacin, and aspirin on the vasodepressor res...
2126584 - A study on the optimal dose of aspirin therapy in kawasaki disease--clinical evaluation...
16669964 - The impact of low-dose aspirin on endoscopic gastric and duodenal ulcer rates in users ...
8708654 - Aspirin at any dose above 30 mg offers only modest protection after cerebral ischaemia.
8244504 - Oral polio vaccination in infants: beneficial effect of additional dose at birth.
3221114 - Cytogenetic effect of dapsone, an antileprotic drug, in the mouse in vivo system.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American surgeon     Volume:  49     ISSN:  0003-1348     ISO Abbreviation:  Am Surg     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1983-10-08     Completed Date:  1983-10-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370522     Medline TA:  Am Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  423-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aspirin / administration & dosage*
Gastric Acid / secretion
Gastric Mucosa / physiopathology
Peptic Ulcer Hemorrhage / physiopathology
Platelet Aggregation / drug effects
Platelet Count
Rats, Inbred Strains
Stomach Ulcer / prevention & control*
Stress, Physiological
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Thrombotic etiology of stress ulcers. 1. The effect of anticoagulant and antiplatelet aggregators in...
Next Document:  Extra-appendicular carcinoid tumors of the gastrointestinal tract.