| The preventive effect of low-dose aspirin in the development of stress ulceration in rats. | |
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MedLine Citation:
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PMID: 6614664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The preventative effect of low-dose aspirin in the development of stress ulcer induced by cold restraint were examined in Sprague-Dawley rats. The bleeding and ulceration scores in the control group were 2.14 and 13.50, respectively. The bleeding score in the 1 mg/kg aspirin group was 1.32 and the ulceration score was 6.89. The scores in 50 mg/kg aspirin group were 2.86 and 38.74, respectively. A significant decrease of ulceration in low-dose aspirin and significant increase in high-dose aspirin were demonstrated. A significant decrease in gastric acid secretion in the low-dose aspirin group was recognized. However, the inhibition of platelet aggregation induced by low-dose aspirin was thought to play a major role in the prevention of stress ulcer. |
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Authors:
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R Kumashiro; O Montgomery; A Langman; A M Kholoussy; T Matsumoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American surgeon Volume: 49 ISSN: 0003-1348 ISO Abbreviation: Am Surg Publication Date: 1983 Aug |
Date Detail:
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Created Date: 1983-10-08 Completed Date: 1983-10-08 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370522 Medline TA: Am Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 423-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aspirin / administration & dosage* Gastric Acid / secretion Gastric Mucosa / physiopathology Male Peptic Ulcer Hemorrhage / physiopathology Platelet Aggregation / drug effects Platelet Count Rats Rats, Inbred Strains Stomach Ulcer / prevention & control* Stress, Physiological |
| Chemical | |
Reg. No./Substance:
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50-78-2/Aspirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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