Document Detail

The prevention of renal impairment in patients undergoing orthotopic liver grafting by infusion of low dose dopamine.
MedLine Citation:
PMID:  3548473     Owner:  NLM     Status:  MEDLINE    
Administration of low dose dopamine (2.0 micrograms/kg/minute) begun before surgery in patients undergoing liver transplantation decreases the incidence of postoperative renal impairment. Thirty-four consecutive patients in the Cambridge/King's College Hospital liver transplantation series were studied. Nineteen patients (21 transplant operations) received prophylactic low dose dopamine throughout the operative and early postoperative period, while 15 patients (15 transplant operations) received dopamine only when clinically indicated for incipient renal failure or as an inotropic agent. In the prophylactic dopamine group, only two transplant operations (9.5%) were complicated by renal impairment, whereas in the other group, 10 patients (67%) developed renal impairment (p = 0.001); of these, four developed acute renal failure (27%). Comparison of seven pairs of patients, matched for age, sex, diagnosis, operative blood loss and operative hypotension (one group receiving dopamine, the other not), revealed a significantly higher urine output in the first 24 hours and creatinine clearance 24-48 hours after surgery (p less than 0.05) in those treated prophylactically. In view of these findings, we would recommend that consideration be given to the prophylactic use of dopamine in patients undergoing orthotopic liver transplantation.
R J Polson; G R Park; M J Lindop; J V Farman; R Y Calne; R Williams
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anaesthesia     Volume:  42     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-04-22     Completed Date:  1987-04-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  15-9     Citation Subset:  AIM; IM    
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MeSH Terms
Child, Preschool
Dopamine / administration & dosage,  therapeutic use*
Infusions, Intravenous
Kidney Failure, Acute / prevention & control*
Liver Transplantation*
Middle Aged
Time Factors

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