Document Detail

The prevention of prosthetic infection using a cross-linked albumin coating in a rabbit model.
MedLine Citation:
PMID:  9331043     Owner:  NLM     Status:  MEDLINE    
We evaluated the effects of a serum protein coating on prosthetic infection in 29 adult male rabbits divided into three groups: control, albumin-coated and uncoated. We used 34 grit-blasted, commercially pure titanium implants. Eleven were coated with cross-linked albumin. All the implants were exposed to a suspension of Staphylococcus epidermidis before implantation. Our findings showed that albumin-coated implants had a much lower infection rate (27%) than the uncoated implants (62%). This may be a useful method of reducing the infection of prostheses.
Y H An; J Bradley; D L Powers; R J Friedman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of bone and joint surgery. British volume     Volume:  79     ISSN:  0301-620X     ISO Abbreviation:  J Bone Joint Surg Br     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-11-06     Completed Date:  1997-11-06     Revised Date:  2010-11-10    
Medline Journal Info:
Nlm Unique ID:  0375355     Medline TA:  J Bone Joint Surg Br     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  816-9     Citation Subset:  AIM; IM    
Medical University of South Carolina, Charleston 29425-2239, USA.
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MeSH Terms
Abscess / pathology,  prevention & control*
Bone Substitutes / adverse effects,  standards*
Disease Models, Animal
Materials Testing
Prosthesis-Related Infections / pathology,  prevention & control*
Random Allocation
Serum Albumin, Bovine / standards*
Staphylococcal Infections / pathology,  prevention & control*
Staphylococcus epidermidis*
Titanium / adverse effects,  standards*
Reg. No./Substance:
0/Bone Substitutes; 0/Serum Albumin, Bovine; 7440-32-6/Titanium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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