Document Detail


The prevention of cholelithiasis with infused sodium chenodeoxycholate in the prairie dog (Cynomys ludovicianus).
MedLine Citation:
PMID:  1679697     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. This study examines the efficacy of infused sodium chenodeoxycholate to prevent cholesterol gallstone formation in the prairie dog when fed a high cholesterol diet. 2. Three experimental groups were designed to examine this. The first group (N = 5) was fed a normal rat chow diet, the second group (N = 5) was fed a high cholesterol diet (0.4% cholesterol by weight), and the third group (N = 5) was fed a high cholesterol diet plus given a daily injection of intravenous sodium chenodeoxycholate (15 mg/kg). 3. All of the animals in the second group had cholesterol crystals and cholesterol gallstones. In the third group, none of the animals had gallstones, and all but one lacked cholesterol crystals. 4. Statistical analysis showed that the first and third groups were statistically identical in their lithogenic indices and biliary lipid composition. 5. We concluded that infused sodium chenodeoxycholate is effective in preventing cholesterol gallstone formation in the prairie dog when fed a high cholesterol diet.
Authors:
G Broughton; A Tseng; R Fitzgibbons; S Tyndall; G Stanislav; E L Rongone
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Comparative biochemistry and physiology. A, Comparative physiology     Volume:  99     ISSN:  0300-9629     ISO Abbreviation:  Comp Biochem Physiol A Comp Physiol     Publication Date:  1991  
Date Detail:
Created Date:  1991-10-16     Completed Date:  1991-10-16     Revised Date:  2008-10-30    
Medline Journal Info:
Nlm Unique ID:  1276312     Medline TA:  Comp Biochem Physiol A Comp Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  609-13     Citation Subset:  IM    
Affiliation:
Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NB 68178.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Bile / metabolism
Chenodeoxycholic Acid / therapeutic use*
Cholelithiasis / prevention & control*
Cholesterol, Dietary / administration & dosage
Gallbladder / metabolism
Lipid Metabolism
Liver / metabolism
Sciuridae
Chemical
Reg. No./Substance:
0/Cholesterol, Dietary; 474-25-9/Chenodeoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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