| The prevalence of vitamin D abnormalities in South Asians with type 2 diabetes mellitus in the UK. | |
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MedLine Citation:
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PMID: 19863680 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: The high prevalence of both hypovitaminosis D and type 2 diabetes (T2DM) in the Asian community is well recognised, but the impact of diabetes on vitamin D status and vice versa, has not been well reported. AIMS: To determine the prevalence of hypovitaminosis D in Asian patients with T2DM and its impact on glycaemic control. METHODS: A cross-sectional study was conducted in a tertiary referral centre in the UK. Two hundred and ten Asian patients aged more than 40 years were included (170 with and 40 without T2DM). Each had a standard bone profile (serum calcium, phosphate and alkaline phosphatase), serum parathyroid hormone and 25-hydroxycholecalciferol. RESULTS: The prevalence of low serum 25-hydroxyvitamin D (< 50 nmol/l) was high in the group as a whole (> 80%) and more common in diabetics compared with controls (83% vs. 70%; p = 0.07). This was particularly so in men (82.5% vs. 57.9%; p = 0.02). HbA1c was higher in women with vitamin D deficiency (< 12.5 nmol/l) (8.11 +/- 1.11% vs. 7.33 +/- 1.32%, p = 0.046). In logistic regression analysis, T2DM was an independent predictor of hypovitaminosis D. In linear regression analysis, vitamin D deficiency was independently related to HbA1c in women with T2DM. CONCLUSIONS: Hypovitaminosis D remains a major public health issue in the Asian population and is exaggerated in patients with T2DM. The fact that vitamin D deficient women had higher HbA1c levels raises the possibility that vitamin D replacement may improve glycaemic control. |
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Authors:
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A A Tahrani; A Ball; L Shepherd; A Rahim; A F Jones; A Bates |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-27 |
Journal Detail:
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Title: International journal of clinical practice Volume: 64 ISSN: 1742-1241 ISO Abbreviation: Int. J. Clin. Pract. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-05-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9712381 Medline TA: Int J Clin Pract Country: England |
Other Details:
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Languages: eng Pagination: 351-5 Citation Subset: IM |
Affiliation:
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School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK. a.a.tahrani@bham.ac.uk |
Export Citation:
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| Comments/Corrections | |
Comment In:
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Int J Clin Pract. 2010 Jul;64(8):1003-4
[PMID:
20642698
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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