Document Detail

The prevalence of thrombophilia in idiopathic osteonecrosis of the hip.
MedLine Citation:
PMID:  20120676     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Thrombophilia is the propensity to develop thrombosis (blood clots) within the vein or artery due to an abnormality in the system of coagulation. It is one of the pathophysiological causes of osteonecrosis of femoral head (ONFH). Previous studies showed that the prevalence of thrombophilia was 1-15% in normal population. There are two types of osteonecrosis of the femoral head, primary osteonecrosis (idiopathic osteonecrosis) and secondary osteonecrosis from other known conditions. There is no previous report of the prevalence of thrombophilia in idiopathic osteonecrosis of the femoral head in Thailand. OBJECTIVE: To study the prevalence of thrombophilia in Thai patients with idiopathic osteonecrosis of the femoral head. MATERIAL AND METHOD: Fifty-five patients with osteonecrosis of femoral head were enrolled in this study. Forty patients had idiopathic osteonecrosis and 15 patients had secondary osteonecrosis. The blood examination of Factor V Leiden mutant, Factor VIII, Protein C, Protein S and Antithrombin III were completed in all subjects. RESULTS: All patients with idiopathic ONFH had bilateral hip involvement. The prevalence of thrombophilia in idiopathic ONFH was 32.5% (13/40). The protein C, protein S deficiencies, and increased factor VIII were the common types of abnormal coagulation in idiopathic ONFH. CONCLUSION: Patients with idiopathic osteonecrosis of the femoral head had a high prevalence of thrombophilia at about 32.5% in contrast to 1-15% in the normal population. The present study suggested that thrombophilia maybe a risk factor of idiopathic osteonecrosis of the femoral head.
Thanainit Chotanaphuti; Danai Heebthamai; Montri Chuwong; Kris Kanchanaroek
Related Documents :
17922806 - Fibrinolysis in patients with an abdominal aortic aneurysm with special emphasis on rup...
6528616 - Substitution of antithrombin iii.
20639306 - Discontinuation of antithrombotic therapy for a year or more in patients with continuou...
6429226 - Intracoronary thrombolysis with an acylated streptokinase-plasminogen activator (brl 26...
15920406 - The impact of prehospital endotracheal intubation on outcome in moderate to severe trau...
6137696 - Acquired immunodeficiency syndrome with severe gastrointestinal manifestations in haiti.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  92 Suppl 6     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-04-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  S141-6     Citation Subset:  IM    
Department of Orthopaedics, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antithrombin III / analysis
Case-Control Studies
Factor V
Factor VIII / analysis
Femur Head Necrosis / epidemiology*,  radiography
Magnetic Resonance Imaging
Middle Aged
Protein C Deficiency / blood
Protein S Deficiency / blood
Risk Factors
Thailand / epidemiology
Thrombophilia / blood,  epidemiology*,  etiology
Young Adult
Reg. No./Substance:
0/factor V Leiden; 9000-94-6/Antithrombin III; 9001-24-5/Factor V; 9001-27-8/Factor VIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The early outcome of Birmingham hip resurfacing: an independent Thai surgeon experiences.
Next Document:  Is magnetic resonance imaging necessary for normal plain radiography evaluation of contralateral non...