Document Detail


The prevalence of testicular adrenal rest tumors and associated factors in postpubertal patients with congenital adrenal hyperplasia caused by 21-hydroxylase deficiency.
MedLine Citation:
PMID:  21521928     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Development of a testicular adrenal rest tumor (TART) is common in males with congenital adrenal hyperplasia, and it can be an important cause of infertility. In the present study, we observed the prevalence of TARTs, and analyzed its associated factors in patients with 21-hydroxylase deficiency. Testicular ultrasonography was performed in 48 postpubertal male patients aged 10.6 to 27.1 years. To determine whether patients were undertreated, we analyzed the serum 17-hydroxyprogesterone (17-OHP) levels to the time of ultrasonographic measurement and calculated the percentage of measurements when serum 17-OHP level was >10 ng/mL relative to the total number of measurements during the follow-up period. We divided the 6-year period before ultrasonographic measurement (time 0) into three 2-year intervals and calculated the average concentration of serum 17-OHP in each interval to give a -2(nd) to 0 year-average concentration (-2-0YAC), -4-2YAC and -6-4YAC. A TART was detected by ultrasonography in 31 of 48 patients (64.6%) and the median maximal cross-sectional area of the TARTs was 0.71 (0.03, 4.95) cm(2). The corrected final adult height was lower, and -4-2YAC and body mass index were higher in patients with TART than in those without. After controlling for the type of 21-hydroxylase deficiency, hydrocortisone-equivalent dose, age, and -6-4YAC, the size of TART was associated with a high undertreatment percentage with a marginal statistical significance. These results suggest that strict disease control is mandatory and regular examination with testicular ultrasonography is recommended in male patients, regardless of the type of 21-hydroxylase deficiency.
Authors:
Min Jae Kang; Jae Hyun Kim; Sun Hee Lee; Young Ah Lee; Choong Ho Shin; Sei Won Yang
Related Documents :
638048 - Histocompatibility antigens in granuloma annulare. comparative study of the generalized...
20838658 - Persistence with statins and onset of rheumatoid arthritis: a population-based cohort s...
10519368 - Polymorphism in the tumor necrosis factor b gene is associated with palmoplantar pustul...
7161778 - Whole body retention of diphosphonate in rheumatoid arthritis.
23357098 - Repeatability of static posturography on the follow-up of vestibular rehabilitation.
3123638 - Comparison of dietary therapy and portacaval shunt in the management of a patient with ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-27
Journal Detail:
Title:  Endocrine journal     Volume:  -     ISSN:  1348-4540     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pediatrics, Seoul National University College of Medicine, Seoul, 110-769, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Clinicopathological features, biochemical and molecular markers in 5 patients with adrenocortical ca...
Next Document:  Prevalence of and risk factors for lipodystrophy among HIV-infected patients receiving combined anti...