Document Detail

The prevalence and stability of an executive processing deficit, response inhibition, in people with chronic schizophrenia.
MedLine Citation:
PMID:  11120436     Owner:  NLM     Status:  MEDLINE    
The current study investigates whether an executive processing measure, response inhibition, is stable over time and across new samples of patients with schizophrenia. Two groups of patients (with and without diagnoses of schizophrenia) were followed up 6 years after baseline data collection. Another separate group of patients with less institutionalized care also completed the same measures to determine whether the response inhibition difficulties had the same prevalence in this new sample.The response inhibition measure was stable over time only in the group of patients with a diagnosis of schizophrenia. The relationship between symptoms and response inhibition difficulties changed over time but was explicable in terms of the interaction between environmental demands and information processing difficulties. The level of response inhibition difficulties (about one-third) was identical in the new sample of patients, which suggests that response inhibition is not dependent on clinical history.
T Wykes; C Reeder; J Corner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Schizophrenia research     Volume:  46     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-02-02     Completed Date:  2001-02-02     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  241-53     Citation Subset:  IM    
Department of Psychology, Institute of Psychiatry, De Crespigny Park, SE5 8AF, London, UK.
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MeSH Terms
Chronic Disease
Cognition Disorders / diagnosis,  epidemiology*,  etiology*
Follow-Up Studies
Inhibition (Psychology)*
Neuropsychological Tests
Reaction Time
Schizophrenia / complications*

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