Document Detail

The prevalence and spectrum of colonic lesions in patients with cirrhotic and noncirrhotic portal hypertension.
MedLine Citation:
PMID:  7737627     Owner:  NLM     Status:  MEDLINE    
Portal hypertension diffusely affects the gastrointestinal tract. The frequency and profile of distinct colonic mucosal lesions (portal colopathy) and rectal varices (RV; veins > 4 cm above the anal verge) is not well studied. Fifty consecutive patients with portal hypertension (25 with cirrhosis, 10 with noncirrhotic portal fibrosis [NCPF], and 15 with extrahepatic portal vein obstruction [EHPVO]) were assessed clinically and by upper and lower gastrointestinal (GI) endoscopy. Colorectal lesions were seen in 35 (70%) patients, significantly more often in bleeders than in nonbleeders. Rectal varices were detected in 22 (44%) patients; larger and more often seen in EHPVO (80%) than in cirrhosis (28%) and NCPF (30%) (P < .01) patients. Portal colopathy was seen in 26 (52%) patients, with nearly similar frequency in cirrhotics, NCPF, and EHPVO patients. Previous sclerotherapy or presence of gastric varices had little influence on the development of these lesions. An association (P < .01) was, however, seen between the presence of colopathy and portal gastropathy. Overt bleeding was seen in 8% and 4% of patients with RV and colopathy, respectively. In conclusion, our results demonstrate that colorectal lesions are present in about two thirds of patients with portal hypertension. Patients with portal hypertension and lower GI bleeding should be colonoscoped. Patients with extrahepatic portal vein obstruction may in turn benefit from baseline sigmoidoscopic examination to define the presence and size of rectal varices.
S Ganguly; S K Sarin; V Bhatia; D Lahoti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  21     ISSN:  0270-9139     ISO Abbreviation:  Hepatology     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-06-02     Completed Date:  1995-06-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1226-31     Citation Subset:  IM    
Department of Gastroenterology, G. B. Pant Hospital, New Delhi, India.
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MeSH Terms
Colonic Diseases / epidemiology*,  etiology*,  pathology
Hypertension, Portal / complications*
Liver Cirrhosis / complications*
Middle Aged
Rectum / blood supply
Stomach / blood supply
Stomach Diseases / etiology
Varicose Veins / etiology

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