| The prevalence of a raised aldosterone-renin ratio (ARR) among new referrals to a hypertension clinic. | |
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MedLine Citation:
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PMID: 16864158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The wider application of the plasma aldosterone to renin activity ratio (ARR) test has led independent groups to report a 10-fold or higher prevalence in the detection and prevalence of primary aldosteronism than previously suggested, although such figures have been contested. We determined the prevalence of a raised ARR in an unselected group of patients who were referred to the hypertension clinic at Aberdeen Royal Infirmary. Over a 4-month period, all newly referred patients had an ARR, urea and electrolytes, and 24-h ambulatory blood pressure monitoring (ABPM) performed in addition to a detailed clinical examination. One hundred and twenty-two patients (mean age 51 +/- 16 years) were examined over the study period; 57 (47%) were receiving no anti-hypertensive medication, 32(26% of total) had a normal 24-h ABPM of which 15 patients were receiving antihypertensive medication ("controlled" hypertensives) and 17(14%) were receiving no anti-hypertensive medication ("white-coat hypertensives). Twenty patients (mean age 58 +/- 11 years) were found to have a raised ARR (> 750), of which 10 patients were receiving beta-blocker therapy as part of their anti-hypertensive regimen. Patients with a raised ARR were more likely (odds ratio 3.6, 95% confidence interval 1.2-13.2, p < 0.05) to be classified as a "non-dipper" compared with those whose blood pressure fell at night. The proportion of newly referred hypertensive patients with a raised ARR is still significant and confirms that of previous studies The ratio appears to be significantly driven by a suppressed renin value and further investigation is required to clarify the status of those patients receiving anti-hypertensive medications, particularly beta-blockers. |
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Authors:
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D Williams; B Croal; J Furnace; S Ross; K Witte; M Webster; W Critchen; J Webster |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Blood pressure Volume: 15 ISSN: 0803-7051 ISO Abbreviation: Blood Press. Publication Date: 2006 |
Date Detail:
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Created Date: 2006-07-25 Completed Date: 2006-09-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9301454 Medline TA: Blood Press Country: Norway |
Other Details:
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Languages: eng Pagination: 164-8 Citation Subset: IM |
Affiliation:
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Department of Clinical Pharmacology, Aberdeen Royal Infirmary, Aberdeen, UK. David.J.Williams@arh.grampian.scot.nhs.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aldosterone / blood* Ambulatory Care Facilities Antihypertensive Agents / therapeutic use Blood Pressure Monitoring, Ambulatory Female Humans Hypertension / blood*, drug therapy Male Middle Aged Prevalence Referral and Consultation Renin / blood* Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 52-39-1/Aldosterone; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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