Document Detail

The prevalence of pulmonary embolism in chronically paralyzed subjects: a review of available evidence.
MedLine Citation:
PMID:  22158255     Owner:  NLM     Status:  MEDLINE    
STUDY DESIGN: Qualitative systematic review.
OBJECTIVES: To examine the validity of the prevailing notion that pulmonary embolism (PE) is rare in the chronic spinal cord injury (SCI) population.
METHODS: Review surveys of adult SCI subjects >2 months after injury in which PE has been looked for and its prevalence estimated.
RESULTS: A total of 16 surveys of chronic SCI subjects published between 1956 and 2009 offered data on PE prevalence. Two autopsy surveys, 178 subjects paralyzed >2 months, revealed no PE. Eleven surveys of the cause of death, 3193 subjects paralyzed 1-25 years, revealed PE in 2.1%. Two surveys of survivors of SCI, 5761 subjects paralyzed 1-25 years, revealed PE in 0.4%. Our survey of 112 subjects paralyzed 1-50 years before death, revealed PE in 21 (18.7%), based on autopsy, imaging, clinical and electrocardiographic evidence. In 7 (33%) of the 21 subjects with PE, pulmonary hypertension by transthoracic echocardiography was detected, indicating recurrent and/or unresolved PE.
CONCLUSION: PE is not infrequent in the chronic SCI subject; but its presentation may be subclinical; and its apparent recurrence may lead to pulmonary hypertension.
J H Frisbie; G V R K Sharma
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-12-13
Journal Detail:
Title:  Spinal cord     Volume:  50     ISSN:  1476-5624     ISO Abbreviation:  Spinal Cord     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-04     Completed Date:  2012-10-05     Revised Date:  2013-01-25    
Medline Journal Info:
Nlm Unique ID:  9609749     Medline TA:  Spinal Cord     Country:  England    
Other Details:
Languages:  eng     Pagination:  400-3     Citation Subset:  IM    
Medical Service, Boston Veterans Affairs Healthcare System, St Paul, MN 55115, USA.
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MeSH Terms
Chronic Disease
Paralysis / etiology
Pulmonary Embolism / epidemiology*,  etiology*
Spinal Cord Injuries / complications*
Comment In:
Spinal Cord. 2012 Dec;50(12):931; author reply 932   [PMID:  23045297 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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