Document Detail


The prevalence of protein C, protein S, and antithrombin III deficiency in non-APS/SLE Chinese adults with noncardiac cerebral ischemia.
MedLine Citation:
PMID:  12812386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Protein C (PC), protein S (PS), and antithrombin III (AT-III) are vital thrombin antagonists in circulation. However, the prevalence of these natural inhibitors for cerebral ischemia is barely mentioned in the Chinese population. The prevalence of PC, PS, and AT-III deficiency in Chinese adults with cerebral ischemia is reported. The study subjects were free of antiphospholipid antibody syndrome or systemic lupus erythematosus. Cardiac, liver, and renal function were normal. An overall rate of thrombophilia was 27%. PS deficiency was the most common disorder, followed by PC with PS and PC deficiency. There was only one patient with AT-III deficiency. No gender was specific for thrombophilia. However, PS deficiency was predilected in young adults. A positive correlation between PC and AT-III was achieved in patients with a normal PC activity but not PC deficiency. There was no correlation between AT-III or PS. The odds ratios of PC and PS were 5.29 and 2.86, respectively. Accordingly, an inability for thrombin antagonization by the PC/PS axis may relate to the occurrence of cerebral ischemia in the Chinese population. AT-III seems to display a minor role only.
Authors:
Wei-Hsi Chen; Min-Yu Lan; Yung-Yee Chang; Shun-Sheng Chen; Jia-Shou Liu
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis     Volume:  9     ISSN:  1076-0296     ISO Abbreviation:  Clin. Appl. Thromb. Hemost.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-06-18     Completed Date:  2003-08-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9508125     Medline TA:  Clin Appl Thromb Hemost     Country:  United States    
Other Details:
Languages:  eng     Pagination:  155-62     Citation Subset:  IM    
Affiliation:
Stroke Biology Research Laboratory, Department of Neurology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antibodies, Anticardiolipin / blood
Antithrombin III Deficiency / epidemiology*
Autoantibodies / blood*
Blood Coagulation Tests
Brain Ischemia / blood*,  complications
Female
Glycoproteins / immunology
Humans
Lupus Coagulation Inhibitor / blood
Male
Middle Aged
Prevalence
Protein C Deficiency / epidemiology*
Protein S Deficiency / epidemiology*
Taiwan / epidemiology
Thrombophilia / epidemiology*,  etiology
beta 2-Glycoprotein I
Chemical
Reg. No./Substance:
0/Antibodies, Anticardiolipin; 0/Autoantibodies; 0/Glycoproteins; 0/Lupus Coagulation Inhibitor; 0/beta 2-Glycoprotein I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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