| The prevalence and prognostic significance of trophoblastic proteins in testicular teratoma. | |
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MedLine Citation:
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PMID: 6676077 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Testicular neoplasms incorporating trophoblastic tumour can contain HCG, SPI and PP5 and have a bad prognosis. These placental proteins also may be localized immunocytochemically in other germ cell tumours in isolated cells which morphologically resemble those in the syncytial layer of trophoblastic tumour, but the prognostic significance of these syncytial giant cells is not established. In sections from 89 malignant teratoma intermediate tumours of pathological stage P1 syncytial giant cells containing HCG were observed in 66 per cent, PP5 in 47 per cent and SPI in 46 per cent. No correlation was observed between the presence of cells staining for each protein and survival at 4 years. Immunocytochemical localization of these proteins in this group of tumours is not a necessary part of a diagnostic service. |
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Authors:
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J R Masters; M C Parkinson; I D Miller; C H Horne |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Diagnostic histopathology / published in association with the Pathological Society of Great Britain and Ireland Volume: 6 ISSN: 0272-7749 ISO Abbreviation: Diagn Histopathol Publication Date: 1983 Jul-Dec |
Date Detail:
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Created Date: 1984-07-23 Completed Date: 1984-07-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8103005 Medline TA: Diagn Histopathol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 247-52 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chorionic Gonadotropin
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analysis* Histocytochemistry Humans Male Neoplasm Proteins / analysis* Pregnancy Proteins / analysis* Prognosis Teratoma / analysis*, pathology Testicular Neoplasms / analysis*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/Neoplasm Proteins; 0/Pregnancy Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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