Document Detail

The prevalence and prognostic significance of trophoblastic proteins in testicular teratoma.
MedLine Citation:
PMID:  6676077     Owner:  NLM     Status:  MEDLINE    
Testicular neoplasms incorporating trophoblastic tumour can contain HCG, SPI and PP5 and have a bad prognosis. These placental proteins also may be localized immunocytochemically in other germ cell tumours in isolated cells which morphologically resemble those in the syncytial layer of trophoblastic tumour, but the prognostic significance of these syncytial giant cells is not established. In sections from 89 malignant teratoma intermediate tumours of pathological stage P1 syncytial giant cells containing HCG were observed in 66 per cent, PP5 in 47 per cent and SPI in 46 per cent. No correlation was observed between the presence of cells staining for each protein and survival at 4 years. Immunocytochemical localization of these proteins in this group of tumours is not a necessary part of a diagnostic service.
J R Masters; M C Parkinson; I D Miller; C H Horne
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diagnostic histopathology / published in association with the Pathological Society of Great Britain and Ireland     Volume:  6     ISSN:  0272-7749     ISO Abbreviation:  Diagn Histopathol     Publication Date:    1983 Jul-Dec
Date Detail:
Created Date:  1984-07-23     Completed Date:  1984-07-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8103005     Medline TA:  Diagn Histopathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  247-52     Citation Subset:  IM    
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MeSH Terms
Chorionic Gonadotropin / analysis*
Neoplasm Proteins / analysis*
Pregnancy Proteins / analysis*
Teratoma / analysis*,  pathology
Testicular Neoplasms / analysis*,  pathology
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Neoplasm Proteins; 0/Pregnancy Proteins

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