Document Detail


The prevalence of peripheral arteriopathy is higher in ischaemic stroke as compared with transient ischaemic attack and intracerebral haemorrhage.
MedLine Citation:
PMID:  20636710     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: There is little data on the association of peripheral arterial disease and stroke. We aimed to assess the prevalence of peripheral arterial disease in acute stroke and to identify the predisposing factors for peripheral arterial disease in a stroke cohort. METHODS: We enrolled all consecutive patients who were admitted to our stroke- and neurocritical care units with the diagnosis of a transient ischaemic attack, ischaemic or haemorrhagic stroke over a period of 5 months. As controls, we analysed 50 nonvascular neurological patients who were matched to age. Upon admission, assessment of the ankle brachial index was performed in all patients. The only exclusion criteria was decompensated congestive heart failure. RESULTS: Altogether, we compared 374 stroke patients (95 transient ischaemic attack, 231 ischaemic, and 48 haemorrhagic strokes) and 50 nonstroke controls. The prevalence of peripheral arterial disease in the control group was 14%. There was a trend towards a higher prevalence of peripheral arterial disease in stroke patients (chi(2)-test: P=0.051; prevalence peripheral arterial disease in transient ischaemic attack: 16.8%, ischaemic stroke: 32%, and haemorrhagic stroke: 20.8%). A higher proportion of ischaemic stroke patients were peripheral arterial disease-positive, compared with transient ischaemic attack patients (P=0.005) and controls (P=0.011), respectively. Multivariate regression analyses identified the parameters age, arterial hypertension, current or former smokers and a history of cardiovascular events to be predisposing factors of peripheral arterial disease. CONCLUSION: This study represents the first systematic investigation of the prevalence of peripheral arterial disease in stroke. By now, it is clear that: * peripheral arterial disease is more commonly found in stroke than in nonstroke patients * ischaemic stroke patients show the highest prevalence of peripheral arterial disease, and * peripheral arterial disease in stroke is related to common vascular risk factors.
Authors:
Hagen B Huttner; Martin Köhrmann; Christoph Mauer; Hannes Lücking; Stephan Kloska; Arnd Doerfler; Stefan Schwab; Peter D Schellinger
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of stroke : official journal of the International Stroke Society     Volume:  5     ISSN:  1747-4949     ISO Abbreviation:  Int J Stroke     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101274068     Medline TA:  Int J Stroke     Country:  England    
Other Details:
Languages:  eng     Pagination:  278-83     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of Erlangen, Erlangen, Germany. martin.koehrmann@uk-erlangen.de
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MeSH Terms
Descriptor/Qualifier:
Aged
Analysis of Variance
Blood Pressure / physiology
Brain Ischemia / complications,  pathology*,  ultrasonography
Cerebral Hemorrhage / complications,  pathology*,  ultrasonography
Cohort Studies
Cross-Sectional Studies
Diabetic Angiopathies / complications
Female
Hemoglobin A, Glycosylated / analysis
Humans
Hypertension / complications
Ischemic Attack, Transient / complications,  pathology*,  ultrasonography
Lipids / blood
Male
Peripheral Vascular Diseases / complications,  pathology*,  ultrasonography
Regression Analysis
Risk Factors
Smoking / epidemiology
Socioeconomic Factors
Stroke / etiology,  pathology*,  ultrasonography
Tomography, X-Ray Computed
Ultrasonography, Doppler, Transcranial
Chemical
Reg. No./Substance:
0/Hemoglobin A, Glycosylated; 0/Lipids

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