| The prevalence of peripheral arteriopathy is higher in ischaemic stroke as compared with transient ischaemic attack and intracerebral haemorrhage. | |
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MedLine Citation:
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PMID: 20636710 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: There is little data on the association of peripheral arterial disease and stroke. We aimed to assess the prevalence of peripheral arterial disease in acute stroke and to identify the predisposing factors for peripheral arterial disease in a stroke cohort. METHODS: We enrolled all consecutive patients who were admitted to our stroke- and neurocritical care units with the diagnosis of a transient ischaemic attack, ischaemic or haemorrhagic stroke over a period of 5 months. As controls, we analysed 50 nonvascular neurological patients who were matched to age. Upon admission, assessment of the ankle brachial index was performed in all patients. The only exclusion criteria was decompensated congestive heart failure. RESULTS: Altogether, we compared 374 stroke patients (95 transient ischaemic attack, 231 ischaemic, and 48 haemorrhagic strokes) and 50 nonstroke controls. The prevalence of peripheral arterial disease in the control group was 14%. There was a trend towards a higher prevalence of peripheral arterial disease in stroke patients (chi(2)-test: P=0.051; prevalence peripheral arterial disease in transient ischaemic attack: 16.8%, ischaemic stroke: 32%, and haemorrhagic stroke: 20.8%). A higher proportion of ischaemic stroke patients were peripheral arterial disease-positive, compared with transient ischaemic attack patients (P=0.005) and controls (P=0.011), respectively. Multivariate regression analyses identified the parameters age, arterial hypertension, current or former smokers and a history of cardiovascular events to be predisposing factors of peripheral arterial disease. CONCLUSION: This study represents the first systematic investigation of the prevalence of peripheral arterial disease in stroke. By now, it is clear that: * peripheral arterial disease is more commonly found in stroke than in nonstroke patients * ischaemic stroke patients show the highest prevalence of peripheral arterial disease, and * peripheral arterial disease in stroke is related to common vascular risk factors. |
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Authors:
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Hagen B Huttner; Martin Köhrmann; Christoph Mauer; Hannes Lücking; Stephan Kloska; Arnd Doerfler; Stefan Schwab; Peter D Schellinger |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of stroke : official journal of the International Stroke Society Volume: 5 ISSN: 1747-4949 ISO Abbreviation: Int J Stroke Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2010-10-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101274068 Medline TA: Int J Stroke Country: England |
Other Details:
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Languages: eng Pagination: 278-83 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Erlangen, Erlangen, Germany. martin.koehrmann@uk-erlangen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Analysis of Variance Blood Pressure / physiology Brain Ischemia / complications, pathology*, ultrasonography Cerebral Hemorrhage / complications, pathology*, ultrasonography Cohort Studies Cross-Sectional Studies Diabetic Angiopathies / complications Female Hemoglobin A, Glycosylated / analysis Humans Hypertension / complications Ischemic Attack, Transient / complications, pathology*, ultrasonography Lipids / blood Male Peripheral Vascular Diseases / complications, pathology*, ultrasonography Regression Analysis Risk Factors Smoking / epidemiology Socioeconomic Factors Stroke / etiology, pathology*, ultrasonography Tomography, X-Ray Computed Ultrasonography, Doppler, Transcranial |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobin A, Glycosylated; 0/Lipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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