Document Detail


The prevalence of non-classic adrenal hyperplasia due to 11 beta-hydroxylase deficiency among hirsute women in a Turkish population.
MedLine Citation:
PMID:  8959074     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The present study was designed to determine the prevalence of 11 beta-hydroxylase deficiency in adult women with hirsutism in a Turkish population. DESIGN AND PATIENTS: One hundred and twenty-four consecutive unselected hirsute patients were studied. An ACTH stimulation test was performed in the midfollicular phase of the cycle on the patients and 20 age-matched controls by administration of a single bolus of 0.25 mg ACTH (1-24) at 0900 h. MEASUREMENTS: Serum 11-deoxycortisol levels were measured before, 30 and 60 minutes after ACTH injection. Basal free testosterone (fT), SHBG, cortisol and androstenedione (A) were also measured. The diagnosis of 11 beta-hydroxylase deficiency has been presumed when the serum 11-deoxycortisol response to ACTH stimulation exceeded three times the 95th percentile of controls. RESULTS: Basal hormone levels including fT and A were significantly higher in the hirsute women than in the healthy women. SHBG was significantly lower in the hirsute patients. Basal and ACTH stimulated 11-deoxycortisol levels were found to be significantly increased in the patients compared with the controls. Eight patients (6.5%) had an 11-deoxycortisol response higher than three times the upper normal limit. CONCLUSIONS: Using stringent diagnostic criteria, we have found that 6.5% of the hirsute women in a Turkish population could be presumed to have 11 beta-hydroxylase deficiency.
Authors:
F Keleştimur; Y Sahin; D Ayata; A Tutuş
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical endocrinology     Volume:  45     ISSN:  0300-0664     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-01-02     Completed Date:  1997-01-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  381-4     Citation Subset:  IM    
Affiliation:
Department of Endocrinology, Erciyes University, Medical School Hospital, Kayseri, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adrenal Hyperplasia, Congenital* / complications,  diagnosis,  epidemiology*
Adult
Androstenedione / blood
Cortodoxone / blood
Cosyntropin / diagnostic use
Female
Hirsutism / epidemiology*,  etiology
Humans
Prevalence
Testosterone / blood
Turkey / epidemiology
Chemical
Reg. No./Substance:
152-58-9/Cortodoxone; 16960-16-0/Cosyntropin; 58-22-0/Testosterone; 63-05-8/Androstenedione

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