Document Detail

The prevalence of gastrinomas in recurrent peptic ulceration.
MedLine Citation:
PMID:  6648499     Owner:  NLM     Status:  MEDLINE    
The prevalence of gastrinomas and the Zollinger-Ellison syndrome is unknown. In order to examine a high risk group of patients, basal and secretin-provoked plasma gastrin levels were determined in 50 consecutive patients, predominantly from the west of Scotland. All had endoscopically proven recurrent peptic ulceration following duodenal ulcer surgery. This resulted in three cases strongly suspected of having a gastrinoma. Further investigations including exploratory laparotomy were unable to demonstrate a gastrinoma in two, but the evidence suggested an occult tumour in one. In this remaining unoperated patient, the serum gastrin returned to normal. The reference range for both basal and secretin stimulated gastrin response and percentage change has been determined in normal control subjects (n = 10) and in primary ulcer patients (n = 20). It is concluded that in this study, gastrinomas had a less than 2 per cent prevalence in patients presenting with recurrent peptic ulceration. As the diagnosis of a gastrinoma changes the surgical approach, conducting screening tests still seems warranted.
J N Primrose; S N Joffe; J G Ratcliffe; K D Buchanan
Related Documents :
2015469 - Non-steroidal anti-inflammatory drugs and complicated diverticular disease: a case-cont...
19579589 - Length of vancomycin administration for treatment of clostridium difficile-associated d...
2079469 - Aetiology of diabetic foot ulceration.
17419799 - Interventions to enhance patient compliance with leg ulcer treatment: a review of the l...
11446879 - Investigation of the extent of gastric metaplasia in the duodenal bulb by using methyle...
10333919 - Causal pathways for incident lower-extremity ulcers in patients with diabetes from two ...
7508259 - The impact of prostatic manipulation upon serum psa in patients with adenocarcinoma of ...
19587469 - An appraisal of blood-cerebrospinal fluid barrier dysfunction during the course of guil...
23925559 - The effect of levothyroxine replacement therapy on lipid profile and oxidative stress p...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scottish medical journal     Volume:  28     ISSN:  0036-9330     ISO Abbreviation:  Scott Med J     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1984-01-27     Completed Date:  1984-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983335R     Medline TA:  Scott Med J     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  328-31     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Duodenal Ulcer / blood
Gastrins / blood,  secretion
Middle Aged
Peptic Ulcer / etiology*
Secretin / diagnostic use
Zollinger-Ellison Syndrome / blood,  complications,  epidemiology*,  secretion
Reg. No./Substance:
0/Gastrins; 1393-25-5/Secretin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Doppler sonography of the extracranial cerebral arteries: primarily a didactic problem
Next Document:  Continuous ambulatory peritoneal dialysis and pulmonary function.