Document Detail


The prevalence of gastrinomas in recurrent peptic ulceration.
MedLine Citation:
PMID:  6648499     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The prevalence of gastrinomas and the Zollinger-Ellison syndrome is unknown. In order to examine a high risk group of patients, basal and secretin-provoked plasma gastrin levels were determined in 50 consecutive patients, predominantly from the west of Scotland. All had endoscopically proven recurrent peptic ulceration following duodenal ulcer surgery. This resulted in three cases strongly suspected of having a gastrinoma. Further investigations including exploratory laparotomy were unable to demonstrate a gastrinoma in two, but the evidence suggested an occult tumour in one. In this remaining unoperated patient, the serum gastrin returned to normal. The reference range for both basal and secretin stimulated gastrin response and percentage change has been determined in normal control subjects (n = 10) and in primary ulcer patients (n = 20). It is concluded that in this study, gastrinomas had a less than 2 per cent prevalence in patients presenting with recurrent peptic ulceration. As the diagnosis of a gastrinoma changes the surgical approach, conducting screening tests still seems warranted.
Authors:
J N Primrose; S N Joffe; J G Ratcliffe; K D Buchanan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scottish medical journal     Volume:  28     ISSN:  0036-9330     ISO Abbreviation:  Scott Med J     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1984-01-27     Completed Date:  1984-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983335R     Medline TA:  Scott Med J     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  328-31     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Duodenal Ulcer / blood
Female
Gastrins / blood,  secretion
Humans
Male
Middle Aged
Peptic Ulcer / etiology*
Recurrence
Scotland
Secretin / diagnostic use
Zollinger-Ellison Syndrome / blood,  complications,  epidemiology*,  secretion
Chemical
Reg. No./Substance:
0/Gastrins; 1393-25-5/Secretin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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