| The prevalence of fragile-X syndrome in an institution for people with learning disability. | |
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MedLine Citation:
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PMID: 9323324 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The prevalence of Fragile-X syndrome in those with learning disability has been reported. There is little agreement regarding the prevalence rate which varies between 0% and 16%. We report a study investigating the prevalence of Fragile-X syndrome in two institutions for those with learning disability, using DNA testing. We found a rate of 0.7%, which is one of the lowest record rates. We also found that physical signs could be used as a reliable discriminator to determine those likely to have the disorder. We conclude that indiscriminate mass screening of those with learning disability for the Fragile-X syndrome is probably not useful because, in adults, physical signs and a family history of learning disability can predict those likely to have the disorder. |
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Authors:
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J O'Dwyer; J Holmes; R Mueller; G Taylor |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Psychiatric genetics Volume: 7 ISSN: 0955-8829 ISO Abbreviation: Psychiatr. Genet. Publication Date: 1997 |
Date Detail:
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Created Date: 1997-11-20 Completed Date: 1997-11-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9106748 Medline TA: Psychiatr Genet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 115-9 Citation Subset: IM |
Affiliation:
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University Department of Psychiatry, Northern General Hospital, Sheffield, UK. J.ODwyer@sheffield.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Body Constitution / genetics England Fragile X Syndrome / epidemiology*, genetics* Humans Institutionalization Male Mental Retardation / genetics* Prevalence Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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