Document Detail

The prevalence of elevated serum C-reactive protein levels in inflammatory and noninflammatory thyroid disease.
MedLine Citation:
PMID:  12964969     Owner:  NLM     Status:  MEDLINE    
C-reactive protein (CRP) levels have not been routinely used to diagnose thyroid disease, although many thyroid conditions involve inflammation. This study was intended to determine whether CRP levels could differentiate between inflammatory and noninflammatory thyroid conditions, especially between type II inflammatory amiodarone-induced thyrotoxicosis (AIT) and type I iodine-induced AIT. Serum high-sensitivity CRP levels were measured in 100 euthyroid controls (7 taking amiodarone) and 353 patients with one of the following thyroid conditions: AIT, subacute thyroiditis, toxic diffuse goiter, nodular goiter, Hashimoto's thyroiditis, shortterm hypothyroidism, or postpartum thyroiditis. No patients with nontoxic multinodular goiter (n = 34), toxic nodular goiter (n = 23), or toxic diffuse goiter, either untreated (n = 49) or euthyroid while taking methimazole (n = 33), had positive CRP levels (>10 mg/L). The occurrence of positive CRP levels among patients with Hashimoto's thyroiditis (n = 35), short-term hypothyroidism (n = 38), and postpartum thyroiditis (n = 70) did not differ significantly from controls. The occurrence of positive CRP values did not differ significantly between patients with type I and type II AIT and controls. Six of 7 patients (86%) with untreated subacute thyroiditis had positive CRP levels (p < 0.00001). These results indicate that there is only a limited role for measurement of CRP levels in the diagnosis of thyroid diseases other than subacute thyroiditis.
Elizabeth N Pearce; Fausto Bogazzi; Enio Martino; Sandra Brogioni; Enia Pardini; Giovanni Pellegrini; Arthur B Parkes; John H Lazarus; Aldo Pinchera; Lewis E Braverman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  13     ISSN:  1050-7256     ISO Abbreviation:  Thyroid     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-09-10     Completed Date:  2004-04-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  United States    
Other Details:
Languages:  eng     Pagination:  643-8     Citation Subset:  IM    
Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
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MeSH Terms
Amiodarone / adverse effects
Anti-Arrhythmia Agents / adverse effects
C-Reactive Protein / metabolism*
Case-Control Studies
Diagnosis, Differential
Middle Aged
Thyroid Diseases / blood*,  diagnosis*
Thyroiditis / blood*,  diagnosis*
Thyrotoxicosis / blood,  chemically induced,  classification,  diagnosis
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 1951-25-3/Amiodarone; 9007-41-4/C-Reactive Protein

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