Document Detail


The prevalence of duodenal lesions in patients with rheumatic diseases on chronic aspirin therapy.
MedLine Citation:
PMID:  6965646     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peroral endoscopy was performed in 56 patients with rheumatic disease who had been taking 8 or more aspirin tablets daily for more than 3 months yet who had no major gastrointestinal symptoms or history of peptic ulcer disease. Duodenal mucosal lesions were observed in 16 patients; 15 (27%) had erythema, 7 (13%) had erosions, and 2 (4%) had ulcers. The prevalence of duodenal lesions was the same in patients taking regular, buffered, or enteric-coated aspirin preparations. Patients with duodenal lesions were more likely to have associated gastric lesions.
Authors:
O O Lockard; K J Ivey; J H Butt; G R Silvoso; C Sisk; S Holt
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gastrointestinal endoscopy     Volume:  26     ISSN:  0016-5107     ISO Abbreviation:  Gastrointest. Endosc.     Publication Date:  1980 Feb 
Date Detail:
Created Date:  1980-05-14     Completed Date:  1980-05-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0010505     Medline TA:  Gastrointest Endosc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  5-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Arthritis, Rheumatoid / drug therapy
Aspirin / adverse effects*,  therapeutic use
Buffers
Duodenal Diseases / chemically induced*,  diagnosis,  epidemiology
Duodenal Ulcer / chemically induced
Endoscopy
Erythema / chemically induced
Female
Humans
Male
Middle Aged
Rheumatic Diseases / drug therapy*
Stomach Ulcer / chemically induced,  epidemiology
Tablets, Enteric-Coated
Chemical
Reg. No./Substance:
0/Buffers; 0/Tablets, Enteric-Coated; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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