Document Detail

The prevalence of diffuse idiopathic skeletal hyperostosis in patients with diabetes mellitus.
MedLine Citation:
PMID:  16167164     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The relation of diffuse idiopathic skeletal hyperostosis (DISH) and diabetes mellitus (DM) has been frequently reported. However, there is little knowledge about its prevalence in DM. The purpose of this study was to determine that prevalence and whether it differs from that of controls. METHODS: The prevalence of DISH was investigated in 133 patients with DM and 133 nondiabetic controls matched for sex, age, and weight. Radiologic criteria were used for diagnosis. Erythrocyte sedimentation rate, fasting blood glucose levels, glycolized hemoglobin, triglyceride, very low-density lipoprotein, low-density lipoprotein, high-density lipoprotein, calcium, uric acid, alkaline phosphatase, phosphorus, insulin, and insulin-like growth factor-1 (IGF1) levels of both groups were compared. RESULTS: The prevalence of DISH (12%) was higher in patients with DM than the control group (6.8%), but there was no statistically significant difference. The average age of the patients diagnosed with DISH (63.36 +/- 9.27) was significantly higher than that of the others (54.21 +/- 12.12) (P < 0.05). There was no significant difference between the DISH patients and the others in other parameters examined. CONCLUSION: We found no statistically significant difference in the prevalence of DISH between patients with DM and controls. We suggest that the factors thought to be responsible for the etiopathogenesis of DISH such as DM, insulin, and insulin-like growth factor-1 be investigated further.
D Sencan; H Elden; V Nacitarhan; M Sencan; E Kaptanoglu
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2004-08-04
Journal Detail:
Title:  Rheumatology international     Volume:  25     ISSN:  0172-8172     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-16     Completed Date:  2005-12-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  518-21     Citation Subset:  IM    
Department of Physical Medicine and Rehabilitation, Medicine Faculty, Cumhuriyet University, 58140, Sivas, Turkey.
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MeSH Terms
Age Distribution
Case-Control Studies
Diabetes Mellitus / diagnosis*,  drug therapy,  epidemiology*
Follow-Up Studies
Hyperostosis, Diffuse Idiopathic Skeletal / diagnosis*,  epidemiology*,  therapy
Middle Aged
Reference Values
Risk Assessment
Severity of Illness Index
Sex Distribution

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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