Document Detail

The prevalence of congenital malaria among neonates with suspected sepsis in Calabar, Nigeria.
MedLine Citation:
PMID:  18453488     Owner:  NLM     Status:  MEDLINE    
We studied the prevalence of congenital malaria among neonates with suspected sepsis and its outcome at the University of Calabar Teaching Hospital, Calabar, Nigeria. All in-born neonates admitted to the newborn unit with clinical features suggestive of sepsis were recruited. They were screened for bacterial sepsis and malaria. The mothers of the neonates that had parasitaemia were further screened for malaria and anaemia. A total of 546 in-born neonates were admitted to the neonatal unit and 202 (37%) presented with clinical signs suggested of sepsis. Of these, 71 babies (35% of 202 or 13% of the total in-born nursery admissions) had congenital malaria and 14 also had sepsis. Sixty-three (88.7%) of the parasitaemic babies were delivered by mothers who received antenatal care at our centre. Eighty-six percent of the mothers of the 71 babies also had the malaria parasite in their blood. The majority (67%) of the 71 mothers were gravidae 2 and below. Thirty (42.3%) of the affected neonates were anaemic and 5 (7%) of them required a blood transfusion. Congenital malarial is not uncommon in Calabar among babies with suspected sepsis. It appears that the antenatal chemoprophylaxis with pyrimethamine (25 mg weekly) currently used for malaria in our centre no longer protects the mother and fetus. An alternative is needed in order to stem maternal, fetal and neonatal morbidity and wastage. Babies with features of sepsis should be routinely screened for malaria.
A D Ekanem; M U Anah; J J Udo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tropical doctor     Volume:  38     ISSN:  0049-4755     ISO Abbreviation:  Trop Doct     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-05-05     Completed Date:  2008-07-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1301706     Medline TA:  Trop Doct     Country:  England    
Other Details:
Languages:  eng     Pagination:  73-6     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, College of Medical Sciences, University of Calabar, Calabar, Nigeria.
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MeSH Terms
Anemia / complications
Bacteremia / complications,  epidemiology,  microbiology
Infant, Newborn
Infectious Disease Transmission, Vertical
Malaria, Falciparum / complications,  congenital*,  epidemiology*,  parasitology
Nigeria / epidemiology
Parasitemia / complications,  epidemiology,  parasitology
Plasmodium falciparum / isolation & purification*
Pregnancy Complications, Parasitic / epidemiology,  parasitology
Sepsis* / complications,  epidemiology,  microbiology,  parasitology

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