Document Detail


The prevalence and clinical characteristics of glucose metabolism disorders in patients with liver cirrhosis. A prospective study.
MedLine Citation:
PMID:  22345342     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: To define the prevalence and clinical characteristics of glucose metabolism disorders (GMD) in patients with compensated liver cirrhosis (LC).
MATERIAL AND METHODS: Fasting plasma glucose (FPG) levels were measured to 130 patients with clinically stable LC. Oral glucose tolerance tests (OGTT) and fasting plasma insulin determinations were performed to patients with normal FPG. Insulin resistance (IR) was calculated with HOMA2-IR index. GMD were classified according to FPG and OGTT tests results and to the chronologic relation between diagnosis of diabetes mellitus (DM) and LC as follows: type-2 DM (T2DM), hepatogenous diabetes (HD) and impaired glucose tolerance. Patients from all groups were compared.
RESULTS: The prevalence of GMD were as follows: T2DM in 25 patients (19.2%, 95% CI 12.5-25.9), HD in 28 (21.5%, 95% CI 14.5-28.5) and IGT in 36 (38.5%, 95% CI 30.1-46.7). The total of patients with GMD was 79.2% (95% CI 72.3-86.1). In 41% of cases GMD were subclinical and 48.7% of patients had IR. Patients with T2DM had a higher number of variables with significant differences compared with the other groups (more marked compared to the patients without GMD). The only differences between the patients with T2DM and HD were hypercreatininemia: 1.14 ± 0.53 vs. 0.84 ± 0.22 mg/dL (p = 0.005) and family history of DM: 8 (32%) vs. 2 (7%) (p = 0.02).
CONCLUSION: Almost 80% of patients with compensated LC had GMD. Half of them were subclinical. The patients with T2DM had marked clinical differences compared to patients from the other groups, particularly renal impairment.
Authors:
Diego García-Compeán; Joel Omar Jáquez-Quintana; Fernando Javier Lavalle-González; Erick Reyes-Cabello; José Alberto González-González; Linda Elsa Muñoz-Espinosa; Genaro Vázquez-Elizondo; Jesús Zacarías Villarreal-Pérez; Héctor J Maldonado-Garza
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of hepatology     Volume:  11     ISSN:  1665-2681     ISO Abbreviation:  Ann Hepatol     Publication Date:    2012 Mar-Apr
Date Detail:
Created Date:  2012-02-20     Completed Date:  2012-07-17     Revised Date:  2013-05-16    
Medline Journal Info:
Nlm Unique ID:  101155885     Medline TA:  Ann Hepatol     Country:  Mexico    
Other Details:
Languages:  eng     Pagination:  240-8     Citation Subset:  IM    
Affiliation:
Gastroenterology Service and Department of Internal Medicine, University Hospital Dr. José E. González and Medical School, Universidad Autónoma de Nuevo León, Monterrey, Mexico. digarciacompean@prodigy.net.mx
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Glucose
Diabetes Mellitus, Type 2* / complications,  epidemiology
Female
Glucose Intolerance* / complications,  epidemiology
Glucose Metabolism Disorders* / complications,  epidemiology,  physiopathology
Glucose Tolerance Test
Humans
Insulin / blood
Insulin Resistance*
Kidney / physiopathology
Liver Cirrhosis* / complications,  physiopathology
Male
Middle Aged
Prospective Studies
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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