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The prevalence of antiphospholipid antibodies in rheumatoid arthritis patients and relationship with disease activity.
MedLine Citation:
PMID:  22910193     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: The importance of antiphospholipid antibodies (aPL) occurrence in rheumatoid arthritis (RA) patients remains unclear. OBJECTIVES: The aim of the study was to assess the prevalence of chosen aPL in RA patients, in correlation with the presence of marker for RA antibodies and with disease activity. PATIENTS AND METHODS: The study group consisted of 97 patients with RA, who had never been treated with biological agents. In all patients serum anticardiolipin antibodies (aCL), anti-beta2-glycoprotein I antibodies (a-β2-GPI),  lupus anticoagulant (LAC), rheumatoid factor in class IgM (RF-IgM) and anti-cyclic citrullinated peptide antibodies (anti-CCP) were measured and disease activity was estimated. RESULTS: The presence of aPL was found in 27 patients (27.8%), among them aCL in 20 patients (20.6%), a-β2-GPI in 12 patients (12.4%) and LAC in 1 patient (1%). Positive aCL of low or medium levels, were detected in IgM class in 11 patients (11.3%) and in IgG class in 12 patients (12.5%). Positive a-β2-GPI of low/medium levels, were found only in IgM class. The presence of LAC was associated with aCL-IgM and a-β2-GPI-IgM. Significant correlation was found between the presence of anti-CCP and different types of aPL. There were no correlation between aPL and RF-IgM presence nor with disease activity markers. CONCLUSIONS: The prevalence of aPL is relatively high in patients with RA. A relationship exists between aPL and RA serological marker antibodies against cyclic citrullinated peptide while significant correlations between disease activity and aPL presence do not exist.  
Authors:
Radosław Jeleniewicz; Maria Majdan; Bożena Targońska-Stępniak; Magdalena Dryglewska
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-22
Journal Detail:
Title:  Polskie Archiwum Medycyny Wewnetrznej     Volume:  -     ISSN:  1897-9483     ISO Abbreviation:  Pol. Arch. Med. Wewn.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401225     Medline TA:  Pol Arch Med Wewn     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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