| The prevalence of airways hyperresponsiveness in members of an exercise training facility. | |
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MedLine Citation:
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PMID: 12870830 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Athletes have a high prevalence (11-50%) of exercise-induced asthma, which may be caused by the hyperventilation accompanying repetitive bouts of strenuous exercise. We hypothesized that recreational exercisers would display a similar trend. Eucapnic voluntary hyperventilation (EVH) bronchoprovocation (breathing 21% O2, 5% CO2, and 74% N2 at 60% of MVV for 5 minutes) was performed to determine the prevalence of airways hyperresponsiveness (AHR) in adults (n=212, 146 males, mean +/- standard deviation, age 32 +/- 10 years) who exercised regularly (10 +/- 10 years, 31 +/- 28% of their lives): none had a previous diagnosis of asthma. AHR was defined by at least a 10%, 20%, or 25% decline in FEV1, FEF(25-75), or PEFR, respectively, by spirometry at 1, 5, 10, and 15 minutes post-EVH. Forty-one of 212 (19%) tested positive for AHR: 20 of 41 (49%) were positive by FEV1, 28 of 41 (68%) by FEF(25-75), and 27 of 41 (66%) by PEFR. Comparing responders with nonresponders: pre-EVH lung function was equivalent, except for FEV1, which was reduced (p<0.05) in responders (96 +/- 13 vs. 102 +/- 12% predicted). Mean maximal negative deflections for responders were: for FEV1, -17 +/- 7%; FEF(25-75), -31 +/- 10%; PEFR, -38 +/- 11%. Ranges of decline for responders were: FEV1, -10 to -33%; FEF(25-75), -20 to -59%; PEFR, -25- to -70%. We conclude that in these regular exercisers, the prevalence of AHR is high and comparable with some athletic populations. |
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Authors:
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Edward T Mannix; Melanie Roberts; Daniel P Fagin; Brandie Reid; Mark O Farber |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of asthma : official journal of the Association for the Care of Asthma Volume: 40 ISSN: 0277-0903 ISO Abbreviation: J Asthma Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-07-21 Completed Date: 2003-08-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8106454 Medline TA: J Asthma Country: United States |
Other Details:
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Languages: eng Pagination: 349-55 Citation Subset: IM |
Affiliation:
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Division of Pulmonary, Allergy, Critical Care and Occupational Medicine, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, USA. emannix@iupui.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Exercise / physiology* Female Humans Male Prevalence Respiratory Function Tests Respiratory Hypersensitivity / epidemiology*, etiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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