Document Detail


The prevalence of Helicobacter pylori infection and the pattern of gastritis in Barrett's esophagus.
MedLine Citation:
PMID:  11549827     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIM: Acid output is related to the gastritis pattern in Helicobacter pylori infection. The hypothesis to be tested is that gastritis in patients with Barrett's esophagus, defined as columnar epithelia lined lower esophagus (CELLO) with intestinal metaplasia (IM), is antrum predominant. PATIENTS AND METHODS: Patients undergoing esophagogastroduodenoscopy were investigated for CELLO. The gastritis parameters H. pylori density, activity, and chronicity were graded in biopsy specimens of antrum and corpus. IM was assessed in biopsies from CELLO patients. In a prospective part, 19 patients with CELLO with IM were compared with 38 age-matched control patient with dyspepsia. RESULTS: Of 200 patients with CELLO, 85% had a short segment (<3 cm), 15% a segment of > or =3 cm. IM was present in 36% of cases with a short CELLO and in 84% of patients with a long segment. The H. pylori prevalence was 50%, independent of the length of CELLO or the presence of IM. The gastritis phenotype was minimally antrum predominant. The antrum/corpus distribution was not related to the length of CELLO or the presence of IM and not different from controls. The activity in corpus and antrum was lower in patients with CELLO with IM as compared with patients with CELLO without IM or controls. CONCLUSIONS: A high proportion of patients with CELLO are H. pylori infected. The pattern of H. pylori gastritis is characterized by a pangastritis with low activity which is not likely to predispose to an increase in acid output after eradication.
Authors:
U Peitz; A Hackelsberger; T Günther; L Clara; P Malfertheiner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Digestive diseases (Basel, Switzerland)     Volume:  19     ISSN:  0257-2753     ISO Abbreviation:  Dig Dis     Publication Date:  2001  
Date Detail:
Created Date:  2001-09-10     Completed Date:  2001-10-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701186     Medline TA:  Dig Dis     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  164-9     Citation Subset:  IM    
Copyright Information:
Copyright 2001 S. Karger AG, Basel
Affiliation:
Department of Gastroenterology, Hepatology, and Infectiology, Otto von Guericke University, Magdeburg, Germany. peitz@medizin.uni-magdeburg.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Barrett Esophagus / etiology,  microbiology,  pathology*
Endoscopy, Digestive System
Female
Gastritis / microbiology,  pathology*
Helicobacter Infections / epidemiology*,  pathology
Helicobacter pylori / pathogenicity*
Humans
Male
Middle Aged
Phenotype
Prevalence
Prospective Studies
Retrospective Studies

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