Document Detail

The preterm prediction study: significance of vaginal infections. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network.
MedLine Citation:
PMID:  7485327     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our purpose was to evaluate the association of bacterial vaginosis, trichomonas vaginitis, and monilial vaginitis with spontaneous preterm birth at < 35 weeks 0 days. STUDY DESIGN: A total of 2929 women at 10 centers were studied at 24 and 28 weeks' gestation by Gram stain of vaginal smear, wet mount, and 10% potassium hydroxide preparations to detect vaginal infections. RESULTS: The rates of detected infection at 24 and 28 weeks, respectively, were bacterial vaginosis 23.4% and 19.4%, trichomonas 3.3% and 2.7%, and monilia 21.1% and 19.5%. The occurrence of bacterial vaginosis at 28 weeks was associated with an increased risk of spontaneous preterm birth, odds ratio 1.84 (95% confidence interval 1.15 to 2.95, p < 0.01). Detection of Trichomonas vaginalis (by wet mount) or monilia (by potassium hydroxide preparation) had no significant associations with preterm birth. CONCLUSION: The presence of bacterial vaginosis at 28 weeks' gestation is associated with an increased risk of spontaneous preterm birth.
P J Meis; R L Goldenberg; B Mercer; A Moawad; A Das; D McNellis; F Johnson; J D Iams; E Thom; W W Andrews
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  173     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1995-12-05     Completed Date:  1995-12-05     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1231-5     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Bowman Gray School of Medicine, Winston-Salem, NC 27157, USA.
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MeSH Terms
Candidiasis, Vulvovaginal / complications,  ethnology
Chi-Square Distribution
Cohort Studies
Logistic Models
Multivariate Analysis
Obstetric Labor, Premature / etiology*
Odds Ratio
Pregnancy Complications, Infectious* / ethnology
Risk Factors
Trichomonas Vaginitis / complications,  ethnology
Vaginal Diseases / complications*,  ethnology
Vaginosis, Bacterial / complications,  ethnology
Comment In:
Am J Obstet Gynecol. 1996 Sep;175(3 Pt 1):754-5   [PMID:  8828453 ]
Am J Obstet Gynecol. 1996 Sep;175(3 Pt 1):753-4   [PMID:  8828452 ]

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