Document Detail

The preterm infant with thrombosis.
MedLine Citation:
PMID:  22562868     Owner:  NLM     Status:  MEDLINE    
In paediatrics, sick preterm infants are at highest risk of developing thrombotic complications. Haemostasis is in a fine balance in the neonatal period, despite age-related differences in coagulation proteins. However, both inherited and acquired risk factors can disrupt this balance and can lead to thrombosis. Important risk factors are sepsis, asphyxia, dehydration, central venous lines and inherited and acquired thrombophilia. Among various treatment modalities, anticoagulation is primarily used in the management of thrombosis. Different agents, dosages and durations of treatment in this age group are extrapolated from adult data. The article reviews the epidemiology, pathophysiology, risk factors, diagnosis and treatment of thrombotic disorders in preterm infants.
Rukhmi Bhat; Paul Monagle
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-05-06
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  97     ISSN:  1468-2052     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-19     Completed Date:  2013-02-05     Revised Date:  2014-01-30    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  England    
Other Details:
Languages:  eng     Pagination:  F423-8     Citation Subset:  AIM; IM    
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MeSH Terms
Anticoagulants / therapeutic use*
Disease Management
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases* / diagnosis,  drug therapy,  etiology
Risk Factors
Thrombosis* / diagnosis,  drug therapy,  etiology
Reg. No./Substance:
Erratum In:
Arch Dis Child Fetal Neonatal Ed. 2014 Jan;99(1):F95

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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