| The presynaptic effects of arachidonic acid and prostaglandin E2 at the frog neuromuscular junction. | |
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MedLine Citation:
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PMID: 16465498 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Arachidonic acid and prostaglandin E2 decreased the frequency of miniature endplate potentials with producing any changes in the their amplitude-time parameters. Arachidonic acid and prostaglandin E2 decreased the quantum composition of endplate currents and the amplitude of the third phase of the nerve ending response, which reflects currents though potential-dependent K+ channels. A perineural method was used to demonstrate that arachidonic acid and prostaglandin E2 suppressed the nerve ending Ca2+ current. The cyclooxygenase blocker indomethacin increased neurotransmitter secretion and decreased the third phase of the nerve ending response. The effects of arachidonic acid and prostaglandin E2 on evoked neurotransmitter release were not seen in the presence of indomethacin, while the third phase of the response continued to show a reduction. It is suggested that prostaglandin E2 mediates the effects of arachidonic acid on spontaneous and evoked neurotransmitter secretion, Ca2+ currents, and Ca2+ -dependent K+ currents. In addition, arachidonic acid and prostaglandin E2 had their own effects on potential-dependent K+ currents in nerve endings. |
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Authors:
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O V Arkhipova; S N Grishin; G F Sitdikova; A L Zefirov |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience and behavioral physiology Volume: 36 ISSN: 0097-0549 ISO Abbreviation: Neurosci. Behav. Physiol. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-02-08 Completed Date: 2006-06-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0330471 Medline TA: Neurosci Behav Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 307-12 Citation Subset: IM |
Affiliation:
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Department of Human and Animals Physiology, Kazan' State University, 18 Kremlevskaya Street, 420008, Kazan', Russia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arachidonic Acid / pharmacology, physiology* Calcium / physiology Cyclooxygenase Inhibitors / pharmacology Dinoprostone / pharmacology, physiology* Indomethacin / pharmacology Motor Endplate / physiology Neuromuscular Junction / drug effects, physiology* Potassium Channels / physiology Rana ridibunda Synapses / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Cyclooxygenase Inhibitors; 0/Potassium Channels; 363-24-6/Dinoprostone; 506-32-1/Arachidonic Acid; 53-86-1/Indomethacin; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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