Document Detail


A presumptive role for leukotrienes in obstructive airways diseases.
MedLine Citation:
PMID:  2990824     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The likelihood that the leukotriene products derived from the 5-lipoxygenase pathway mediate aspects of obstructive airways diseases is strongly suggested by their documented capacities to effect airway spasmogenicity, airway hyperreactivity, tissue edema formation, mucus secretion, and tissue infiltration by leukocytes. That the various leukotriene components of SRS-A have unique receptors on responding tissues and are recoverable from airway surfaces in several inflammatory lung diseases and that several resident and infiltrating cell types have significant potential for leukotriene biosynthesis lend further support to their postulated pathobiologic roles. To fulfill Koch's postulates for proof of leukotrienes' etiologic role, it remains to be shown that inhibition of their biosynthesis or specific antagonism at their end-organ receptors can greatly ameliorate these disease states.
Authors:
R A Lewis
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Chest     Volume:  88     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-09-05     Completed Date:  1985-09-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  98S-102S     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arachidonate Lipoxygenases
Bronchial Spasm / physiopathology
Dose-Response Relationship, Drug
Humans
Hydroxyeicosatetraenoic Acids / metabolism
Leukotriene B4 / metabolism,  pharmacology,  physiology*
Lipoxygenase / metabolism
Lung / drug effects,  physiopathology
Lung Diseases, Obstructive / metabolism,  physiopathology*
Macrophages / metabolism
Mast Cells / metabolism
Monocytes / metabolism
Pulmonary Alveoli / cytology
Pulmonary Ventilation
Receptors, Leukotriene
Receptors, Prostaglandin / analysis,  metabolism
SRS-A / metabolism,  pharmacology,  physiology*
Vital Capacity
Grant Support
ID/Acronym/Agency:
AI-00399/AI/NIAID NIH HHS; AI-20081/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Hydroxyeicosatetraenoic Acids; 0/Receptors, Leukotriene; 0/Receptors, Prostaglandin; 0/SRS-A; 71160-24-2/Leukotriene B4; 72255-35-7/5-hydroxy-6,8,11,14-eicosatetraenoic acid; EC 1.13.11.-/Arachidonate Lipoxygenases; EC 1.13.11.12/Lipoxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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