Document Detail

The pressor response to venous cannulation: attenuation by prior infiltration with local anaesthetic.
MedLine Citation:
PMID:  8318323     Owner:  NLM     Status:  MEDLINE    
We have compared the cardiovascular response to insertion of an 18-gauge venous cannula in 40 healthy patients. In 20 of the patients, cannulation was preceded by infiltration of local anaesthetic. Both rate-pressure product and mean arterial pressure increased significantly (P < 0.01) compared with baseline when no local infiltration was used, but there was no significant change from baseline when infiltration with local anaesthetic preceded cannulation. We conclude that there is a significant pressor response to venous cannulation which is obtunded by prior infiltration with local anaesthetic. We recommend, therefore, that s.c. injection of lignocaine should be considered before insertion of an i.v. cannula, especially in the high risk patient.
B T Langham; D A Harrison
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  70     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-08-03     Completed Date:  1993-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  519-21     Citation Subset:  IM    
University of Nottingham, Nottingham City Hospital.
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MeSH Terms
Anesthetics, Local / administration & dosage*
Blood Pressure / drug effects,  physiology*
Catheterization, Peripheral*
Lidocaine / administration & dosage
Middle Aged
Time Factors
Reg. No./Substance:
0/Anesthetics, Local; 137-58-6/Lidocaine
Comment In:
Br J Anaesth. 1993 Oct;71(4):612-3   [PMID:  8260319 ]
Br J Anaesth. 1993 Oct;71(4):613   [PMID:  8260320 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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