Document Detail

The pressor response to venous cannulation: attenuation by prior infiltration with local anaesthetic.
MedLine Citation:
PMID:  8318323     Owner:  NLM     Status:  MEDLINE    
We have compared the cardiovascular response to insertion of an 18-gauge venous cannula in 40 healthy patients. In 20 of the patients, cannulation was preceded by infiltration of local anaesthetic. Both rate-pressure product and mean arterial pressure increased significantly (P < 0.01) compared with baseline when no local infiltration was used, but there was no significant change from baseline when infiltration with local anaesthetic preceded cannulation. We conclude that there is a significant pressor response to venous cannulation which is obtunded by prior infiltration with local anaesthetic. We recommend, therefore, that s.c. injection of lignocaine should be considered before insertion of an i.v. cannula, especially in the high risk patient.
B T Langham; D A Harrison
Related Documents :
1375693 - Effects of milrinone on systemic capacitance vessels in relation to venous return and r...
15205863 - Pressure measurements in arterial feeders of brain arteriovenous malformations before a...
20726993 - Reference values for respiratory pressures in a general adult population--results of th...
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  70     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-08-03     Completed Date:  1993-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  519-21     Citation Subset:  IM    
University of Nottingham, Nottingham City Hospital.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anesthetics, Local / administration & dosage*
Blood Pressure / drug effects,  physiology*
Catheterization, Peripheral*
Lidocaine / administration & dosage
Middle Aged
Time Factors
Reg. No./Substance:
0/Anesthetics, Local; 137-58-6/Lidocaine
Comment In:
Br J Anaesth. 1993 Oct;71(4):612-3   [PMID:  8260319 ]
Br J Anaesth. 1993 Oct;71(4):613   [PMID:  8260320 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Partial reversal of the effects of extradural clonidine by oral yohimbine in postoperative patients.
Next Document:  Surfactant and adult respiratory distress syndrome.