Document Detail

The pressor effect of exogenous angiotensin II is diminished during dynamic exercise.
MedLine Citation:
PMID:  6599496     Owner:  NLM     Status:  MEDLINE    
To evaluate the effect of dynamic exercise on the response to angiotensin II (AII), AII (7.5 ng/kg/min) or vehicle (P) was infused intravenously in seven normal sodium replete volunteers before, during and after a graded uninterrupted exercise test until exhaustion, using a randomized cross-over protocol. Plasma angiotensin II (PAII) during AII infusion was an average 86-145 pg/ml higher than during P. The differences in mean intra-arterial pressure between the AII and the P tests averaged 17 mmHg at recumbent rest, 12 mmHg in the sitting position on the bicycle ergometer and 7 mmHg at 20% of peak work rate declining progressively throughout the exercise test to become insignificant from 80% of peak work rate on. A significant difference reappeared after exercise. It is suggested that the powerful vasoconstriction in some vascular beds and the dilatation in others oppose the vasoconstricting effect of AII; other possible mechanisms are changes in pH and a decrease of the difference in log PAII between the AII and P tests with increasing levels of endogenous PAII during exercise.
R Fagard; P Lijnen; A Amery
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  1     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1986-02-18     Completed Date:  1986-02-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  49-51     Citation Subset:  IM    
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MeSH Terms
Acidosis / blood
Angiotensin II / blood,  pharmacology*
Blood Pressure / drug effects*
Hydrogen-Ion Concentration
Physical Exertion*
Reference Values
Reg. No./Substance:
11128-99-7/Angiotensin II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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