| The pressor effect of exogenous angiotensin II is diminished during dynamic exercise. | |
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MedLine Citation:
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PMID: 6599496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate the effect of dynamic exercise on the response to angiotensin II (AII), AII (7.5 ng/kg/min) or vehicle (P) was infused intravenously in seven normal sodium replete volunteers before, during and after a graded uninterrupted exercise test until exhaustion, using a randomized cross-over protocol. Plasma angiotensin II (PAII) during AII infusion was an average 86-145 pg/ml higher than during P. The differences in mean intra-arterial pressure between the AII and the P tests averaged 17 mmHg at recumbent rest, 12 mmHg in the sitting position on the bicycle ergometer and 7 mmHg at 20% of peak work rate declining progressively throughout the exercise test to become insignificant from 80% of peak work rate on. A significant difference reappeared after exercise. It is suggested that the powerful vasoconstriction in some vascular beds and the dilatation in others oppose the vasoconstricting effect of AII; other possible mechanisms are changes in pH and a decrease of the difference in log PAII between the AII and P tests with increasing levels of endogenous PAII during exercise. |
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Authors:
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R Fagard; P Lijnen; A Amery |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hypertension. Supplement : official journal of the International Society of Hypertension Volume: 1 ISSN: 0952-1178 ISO Abbreviation: J Hypertens Suppl Publication Date: 1983 Dec |
Date Detail:
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Created Date: 1986-02-18 Completed Date: 1986-02-18 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8501422 Medline TA: J Hypertens Suppl Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 49-51 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis
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blood Adult Angiotensin II / blood, pharmacology* Blood Blood Pressure / drug effects* Humans Hydrogen-Ion Concentration Male Physical Exertion* Reference Values Rest |
| Chemical | |
Reg. No./Substance:
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11128-99-7/Angiotensin II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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