Document Detail


The presence and possible role of monocyte infiltration in human chronic proliferative glomerulonephritides. Light microscopic, immunofluorescence, and histochemical correlations.
MedLine Citation:
PMID:  371410     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty-seven cases of chronic glomerulonephritis with proliferative pattern (11 cases of primary mixed IgG-IgM cryoglobulinemia, 8 cases of SLE, and 8 cases of primary membranoproliferative glomerulonephritis) were studied with particular attention to the glomerular monocyte infiltration. The latter, detected by means of nonspecific esterase technique, was compared with the presence of hyaline thrombi and intraluminal immunoglobulin lumps. Monocyte infiltration was heavy and almost constant in cryoglobulinemia, less important in SLE, and practically absent in membranoproliferative glomerulonephritis. By means of immunofluorescence technique on paraffin embedded material, monocytes are shown to contain IgG and IgM, suggesting a phagocytic activity on some types of immune complexes. Since monocytes are migrant cells, and therefore easily removable from the glomeruli by the bloodstream, it seems that they could be responsible for regression of glomerular hypercellularity as reported in some patients with cryoglobulinemia showing clinical improvement.
Authors:
G Monga; G Mazzucco; G B di Belgiojoso; G Busnach
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of pathology     Volume:  94     ISSN:  0002-9440     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1979-05-16     Completed Date:  1979-05-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  271-84     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Chronic Disease
Cryoglobulins
Fluorescent Antibody Technique
Glomerulonephritis / pathology*
Humans
Immunoglobulin G
Immunoglobulin M
Inflammation / pathology
Lupus Erythematosus, Systemic / immunology,  pathology
Monocytes / pathology*
Paraproteinemias / immunology,  pathology
Chemical
Reg. No./Substance:
0/Cryoglobulins; 0/Immunoglobulin G; 0/Immunoglobulin M
Comments/Corrections

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