Document Detail

The presence of maternal asthma during pregnancy suppresses the placental pro-inflammatory response to an immune challenge in vitro.
MedLine Citation:
PMID:  21453968     Owner:  NLM     Status:  MEDLINE    
The mechanisms that contribute to adverse outcomes for the neonate in pregnancies complicated by asthma may be mediated via changes in placental immune function. This study was designed to determine whether the presence of maternal asthma during pregnancy alters the placental pro-inflammatory immune response in vitro. A prospective cohort study of women with asthma (n = 22) and control (n = 11) subjects had placentae collected immediately after delivery. Placental explants were exposed to an immune challenge, lipopolysaccharide, in the presence and absence of cortisol in vitro. Cytokines, glucocorticoid receptor α (GR α) and p38 MAPK protein were measured. Placentae of control pregnancies had an increase in pro-inflammatory cytokine production over a 24 h period. Placentae from pregnancies complicated by maternal asthma had a reduced pro-inflammatory cytokine response to an immune challenge relative to the controls especially in relation to the production of interleukin (IL)-1β and TNFα regardless of fetal sex. Cortisol inhibition of placental cytokine production was dependent on timing of exposure, fetal sex and presence and absence of asthma. GRα and p38 MAPK protein expression did not appear to contribute to differences in response to endotoxin or cortisol. Maternal asthma during pregnancy induces a hyposensitive inflammatory state in the placenta which is regulated by cortisol in a sexually dimorphic manner.
N M Scott; N A Hodyl; A Osei-Kumah; M J Stark; R Smith; V L Clifton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-03-31
Journal Detail:
Title:  Placenta     Volume:  32     ISSN:  1532-3102     ISO Abbreviation:  Placenta     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-17     Completed Date:  2011-09-12     Revised Date:  2011-12-12    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  454-61     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Mothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.
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MeSH Terms
Adjuvants, Immunologic / pharmacology*
Asthma / immunology,  physiopathology*
Blotting, Western
Cohort Studies
Cytokines / metabolism*
Immunity, Innate / drug effects
Infant, Newborn
Lipopolysaccharides / pharmacology*
Placenta / drug effects*,  immunology*
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Cytokines; 0/Lipopolysaccharides
Comment In:
Placenta. 2011 Nov;32(11):922   [PMID:  21641032 ]

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